急性脑血管病院内感染危险因素及H2受体阻滞剂应用相关性分析

目的 探讨急性脑血管病患者住院期间使用H2受体阻滞剂预防应激性溃疡与医院感染的关系.方法 对612例脑血管病患者进行院内感染易感因素分析.单因素分析院内感染的危险因素,并根据患者48hGlassgow评分分层分析使用H2受体阻滞剂与医院感染的关系.结果 612例脑血管病患者住院期间感染发生率为34.48%,其中患者卒中类型、吞咽困难、H2受体阻滞剂使用、昏迷程度及侵入性操作是发生院内感染的主要危险因素.患者入院后48h Glassgow评分9～15时,使用H2受体阻滞剂预防应激性溃疡能显著增加患者院内感染的发生率(P<0.001);入院后48h Glassgow评分≤8分时,使用H2受体阻滞剂对患者发生感染无明显影响.结论 急性脑血管病患者使用H2受体阻滞剂预防应激性溃疡与院内感染有密切相关.

Abstract：

Objective To investigate the relationship between using H2 receptor antagonists to prevent stress ulcers and infectious complications in patients with acute cerebrovascular disease in hospital. Methods 612 acute cerebrovascular disease inpatients were analysised for the risk factors of in hospital infection. The single factors of nosocomial infection were analysed. According to patients with 48 hours Glassgow score, the relationship between nosocomial infection and using H2 receptor blockers were also stratified studied. Results The incidence of infection of 612 acute cerebrovascular disease patients was 34. 48% . Type of stroke, dysphagy, using H2 receptor antagonists, degrees of coma and invasive manipulation were mainly risk factors of the incident of nosocomial infection. When the patients Glassgow scores of 48 hours after admission were 9 ～ 15, using H2 receptor antagonists to prevent stress ulcers significantly increased the incidence of nosocomial infection. When the patients Glassgow scores of 48 hours after admission were no more than 8 , using H2 receptor antagonists didnt have a great influence on nosocomial infection. Conclusions Using H2 receptor antagonists to prevent stress ulcers was closely related to nosocomial infection in Inpatients with acute cerebrovascular diseases.

Analysis of the relationship between using H2 receptor antagonists and nosocomial infection of the patients with acute cerebrovascular diseases

Objective To investigate the relationship between using H2 receptor antagonists to prevent stress ulcers and infectious complications in patients with acute cerebrovascular disease in hospital. Methods 612 acute cerebrovascular disease inpatients were analysised for the risk factors of in hospital infection. The single factors of nosocomial infection were analysed. According to patients with 48 hours Glassgow score, the relationship between nosocomial infection and using H2 receptor blockers were also stratified studied. Results The incidence of infection of 612 acute cerebrovascular disease patients was 34. 48% . Type of stroke, dysphagy, using H2 receptor antagonists, degrees of coma and invasive manipulation were mainly risk factors of the incident of nosocomial infection. When the patients Glassgow scores of 48 hours after admission were 9 ～ 15, using H2 receptor antagonists to prevent stress ulcers significantly increased the incidence of nosocomial infection. When the patients Glassgow scores of 48 hours after admission were no more than 8 , using H2 receptor antagonists didnt have a great influence on nosocomial infection. Conclusions Using H2 receptor antagonists to prevent stress ulcers was closely related to nosocomial infection in Inpatients with acute cerebrovascular diseases.