奥氮平对谷氨酸功能低下的精神分裂症小鼠模型的作用 |
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引用本文: | 苏允爱,司天梅,郭春梅,杨阳,冯瑜,李继涛. 奥氮平对谷氨酸功能低下的精神分裂症小鼠模型的作用[J]. 中华精神科杂志, 2009, 43(4): 111-115. DOI: 10.3760/cma.j.issn.1006-7884.2010.02.015 |
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作者姓名: | 苏允爱 司天梅 郭春梅 杨阳 冯瑜 李继涛 |
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作者单位: | 卫生部精神卫生学重点实验室,北京大学精神卫生研究所,100191; |
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摘 要: | Objective To investigate the effects of olanzapine on hyperlocomotion and deficient prepusle inhibition (PPI) of hypoglutamatergic schizophrenia model in mice produced by dizocilpine maleate (MK-801), an N-methyl-D-aspartate (NMDA)antagonist.Methods (1) To investigate the effects of olanzapine on explorative behavior and spontaneous activity, three doses of olanzapine ( 0.1, 0.2, 0.3 mg/kg, i.p.) or vehicle was injected 30 min before the test.Locomotor activity was recorded for 30 min with an automated video tracking system, in which the components of the locomotor activity were divided into exploration (the first 10 min) and spontaneous activity (the second 20 min).(2) To examine the effects of olanzapine on MK-801-induced hyperlocomotion, mice were administered with olanzapine (0.1, 0.2 and 0.3 mg/kg) or vehicle 5 min before administration of MK-801 (0.25 mg/kg).After the second injection, locomotor activity was recorded for 90 min by the video tracking system.( 3 ) To explore the effects of olanzapine on intact and MK-801-disrupted sensorimotor gating, olanzapine (0.3, 1,3 mg/kg, i.p.) or the vehicle were injected 35 min before the start of the experiment, MK-801 (0.5 mg/kg, i.p.) or the same volume of saline was administered 5 min before the PPI experiment.Results ( 1 ) Olanzapine (0.2 and 0.3 mg/kg) significantly inhibited the explorative behavior and spontaneous activity (P < 0.05 ) .Olanzapine at 0.1 mg/kg did not affect exploration ( P = 0.363 ) and spontaneous activity ( P = 0.196 ).Olanzapine (0.1 - 0.3 mg/kg) dose-dependently antagonized MK-801 -induced hyperlocomotion.(2) None of the olanzapine doses tested had a significant effect on baseline PPI.Olanzapine ( 1 - 3 mg/kg) dosedependently restored the MK-801-induced deficits in PPI.Conclusion Olanzapine specifically inhibited the MK-801-induced hyperlocomotion and deficits in PPI in mice and the results are also consistent with clinical findings.
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关 键 词: | 地卓西平马来酸盐 奥氮平 精神分裂症 运动活动 抑制(心理学) |
Effects of olanzapine on the hypoglutamatergic schizophrenia model in mice |
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Abstract: | |
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Keywords: | Dizocilpine maleateOlanzapineSchizophreniaLocomotor activityInhibition (psychology) |
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