| 首次发病未用药老年抑郁症患者脑白质完整性的弥散张量成像研究 |
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| 引用本文： | 寻广磊,陈晋东,赵靖平,刘海洪,贺忠,李丽. 首次发病未用药老年抑郁症患者脑白质完整性的弥散张量成像研究[J]. 中华精神科杂志, 2009, 43(4): 75-78. DOI: 10.3760/cma.j.issn.1006-7884.2010.02.005 |
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| 作者姓名： | 寻广磊 陈晋东 赵靖平 刘海洪 贺忠 李丽 |
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| 作者单位： | 中南大学湘雅二医院精神卫生研究所,长沙,410011;中南大学湘雅医院临床心理中心;中南大学湘雅二医院放射科,长沙,410011; |
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| 基金项目： | 中央保健委基金资助项目 |
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| 摘 要： | Objective To explore the white matter integrity by using diffusion tensor imaging (DTI) in first-episode, medication-naive geriatric patients with major depressive disorder.Methods Fifteen first-episode, medication-naive depressive patients and fifteen healthy controls underwent DTI scan.Fractional anisotropy (FA) of white matter was compared between the two groups using voxel-based approach.Results Compared with healthy controls, geriatric depressive patients showed significantly lower FA in left anterior cingulate (cluster size = 106 voxels, t = 3.21 ), right anterior cingulate ( cluster size =60 voxels, t = 2.71 ), right subgenual cingulate ( cluster size = 63 voxels, t = 3.37 ) and left brainstem ( cluster size = 62 voxels, t = 3.25 ) ( level of significance was uncorrected single-tailed P ＜ 0.01, threshold of cluster size ＞ 50 voxels).Conclusion Decrease of white matter integrity in bilateral anterior cingulate and right subgenual cingulate are present in the early stage of geriatric depression.Lesions of neural pathways by way of these regions may be involved in the pathophysiology of geriatric depression.
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| 关 键 词： | 抑郁症 老年人 磁共振成像,弥散 脑 各向异性 |
Abnormalities of white matter integrity detected by diffusion tensor imaging in first-episode, medication-naive geriatric depression |
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| Abstract: | |
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| Keywords: | Depressive disorderAgedDiffusion magnetic resonance imagingBrainAnisotropy |
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