高压氧治疗对中重型颅脑损伤患者脑干和体感诱发电位的影响及疗效分析

目的 观察高压氧(hyperbaric oxygen,HBO)治疗对外伤性中重型颅脑损伤患者脑干听觉诱发电位(bralnstem auditory evoked potential,BAEP)、体感诱发电位(somatic evoked potential,SEP)的影响及其治疗效果.方法 134例外伤性中重型颅脑损伤患者分为对照组67例和HBO治疗组67例.对照组采用必要的神经外科处理及常规药物治疗;HBO组在对照组治疗的基础上,病情稳定后加用3个疗程的HBO治疗.治疗前后行BAEP、SEP检查及格拉斯哥昏迷评分(GCS),伤后6个月随访行格拉斯哥预后评分(GOS).结果 治疗前2组患者BAEP、SEP异常率及GCS评分差异无统计学意义(P>0.05);治疗后对照组BAEP明显改善(P<0.05),SEP改善更为显著(P<0.01),GCS评分明显升高(P<0.05),HBO组BAEP、SEP改善均有统计学意义(P<0.01),GCS评分提高有统计学意义(P<0.01);治疗后HBO组BAEP、SEP异常率与对照组比较差异有统计学意义(P<0.01),GCS评分与对照组比较差异有统计学意义(P<0.05);伤后6个月GOS评分显示HBO组预后良好患者较对照组明显增多(P<0.01),死亡率则明显降低(P<0.05).结论 HBO可明显改善中重型颅脑损伤患者BAEP及SEP的异常情况,提高临床疗效.

Effects of hyperbaric oxygen on brainstem auditory evoked potential and somatic evoked potential of patients with moderate and severe traumatic brain injury and analysis of its therapeutic efficiency

Objective To investigate effects of hyperbaric oxygen (HBO) on brainstem auditory evoked potential (BAEP) and somatic evoked potential (SEP)of patients with moderate and severe trauma tic brain injury and to analyze its therapeutic efficiency. Methods One hundred and thirty-four patients with moderate and severe trauma brain injury were randomly divided into the control group (67 cases) and the HBO adjunctive therapy group (HBO group, 67 cases). The control group received essential neurosurgical treatment and conventional drug treatment, and the HBO group was given HBO therapy for three sessions in addition to the same treatment received by the control group. BAEP and SEP were detected and the scores of Glasgow coma scale (GCS) were measured before and after treatment. Glasgow outcome scale (GOS) were evaluated in follow - ups 6 months after injury. Results Abnormality of BAEP, SEP and GCS for the patients of both groups showed no statistical difference before treatment (P > 0.05). After treatment, significant improvement could be seen in BAEP of the control group(P <0. 05), and more significant improvement was noted in SEP (P <0.01), GCS also increased significantly in the control group (P <0.05). For the HBO group, BAEP and SEP all improved