雄激素受体在雄性激素源性脱发患者的表达观察

目的：了解雄激素受体（AR）在雄性激素源性脱发（AGA）患者顶部表皮、毛囊、皮脂腺、汗腺中的表达情况。方法：选取26例雄性激素源性脱发患者顶部、枕部以及10例非脱发者的顶部头皮标本，用免疫组织化学检测表皮、毛囊、皮脂腺、汗腺中AR的表达。结果：脱发患者头顶部毛囊、皮脂腺、汗腺AR表达均明显强于枕部和非脱发者枕部，差异均有统计学意义（P〈0.05）；脱发患者枕部毛囊、皮脂腺、汗腺AR表达与非脱发者顶部AR表达比较差异均无统计学意义（P〉0.05）；所有标本表皮中AR均为阴性。结论：AR在AGA患者头顶部毛囊、皮脂腺、汗腺的高表达，可能是AGA重要原因之一。

The Observation of Androgen Receptor Expression in Androgenetic Alopecia Patients

To investigate AR expression in the top of epidermis,hair follicle and sebaceous gland, sudoriferous gland.Method：The top and the occipital scalp of AGA patients（n=26）and the top scalp of non-alopecia people（n=10）as specimens were obtained,and AR expressions in the epidermis,hair follicle and sebaceous gland, sudoriferous gland were studied by immunohistochemistry method.Result：AR expressions of hair follicle,sebaceous gland,sudoriferous gland on the top of AGA patients were stronger than the occipital of AGA patients and the top of non-alopecia（P〈0.05）;AR expressions of hair follicle,sebaceous gland,sudoriferous gland in the occipital of AGA patients had no significant difference with the top of non-alopecia（P〉0.05）. All samples were negative for AR in epidermis. Conclusion：AR expressions on the top of hair follicle and sebaceous gland,sudoriferous gland in AGA patients may be one of the key factors leading to AGA.