|
|||||
|
|
| 睾丸酮、雌二醇和棉酚合并用药的雄性抗生育作用及其安全性的研究 | |
| 引用本文： | 叶惟三,但凌,郭燕,钱晓菁,应骏,薛社普. 睾丸酮、雌二醇和棉酚合并用药的雄性抗生育作用及其安全性的研究[J]. 药学学报, 1996, 31(4): 313-315 |
| 作者姓名： | 叶惟三 但凌 郭燕 钱晓菁 应骏 薛社普 |
| 作者单位： | 中国医学科学院，中国协和医科大学基础医学研究所 |
| 摘 要： | 睾丸酮、雌二醇和棉酚合并用药的雄性抗生育作用及其安全性的研究叶惟三，但凌，郭燕，钱晓菁，应骏，薛社普（中国医学科学院，中国协和医科大学基础医学研究所，北京１００００５）减轻有抗男性生育活性棉酚的副作用是发展棉酚成为男性避孕药急待解决的问题［１，２］。... |
| 关 键 词： | 睾丸酮；雌二醇；棉酚；抗生育作用 |
| 收稿时间： | 1995-07-08 |
THE ANTIFERTILITY EFFECT OF GOSSYPOL PLUS TESTOSTERONE AND ESTEROGEN |
|
| WS Ye,L Dan,XJ Qian,J Ying and SP Xue. THE ANTIFERTILITY EFFECT OF GOSSYPOL PLUS TESTOSTERONE AND ESTEROGEN[J]. Acta pharmaceutica Sinica, 1996, 31(4): 313-315 | |
| Authors: | WS Ye L Dan XJ Qian J Ying SP Xue |
| Abstract: | In order to reduce the side effect of gossypol,gossypol was used in conbination with steroid hormones so that the dose of both drugs can be reduced,Silastic capsules containing testosterone(T)+estradiol(E) were implanted under the skin male wister rats for 8 weeks,After removing the implants,testosterone was given orally at the dose of 15mg·kg-1 which is only 50% of the usual antifertility dose.Mating tests showed that the male rats became infertile.Microscopic examination of the heart,liver and kidneys showed no pathologic changes.The treated rats gained body weight as well as the controls.The fertility of the treated rats recovered four to five weeks after treatment.Thus,gossypol in combination with testosterone and estrogen exhibited a low degree of side effect and high antifertility activity. |
| Keywords: | es Testosterone Estrogen Gossypol Antifertility effect |
| 本文献已被 CNKI 维普 等数据库收录！ | |
| 点击此处可从《药学学报》浏览原始摘要信息 | |
| 点击此处可从《药学学报》下载全文 | |