江苏地区幽门螺杆菌感染及其危险因素调查

目的:进一步了解我国胃癌高发区Hpylori流行状况及危险因素.方法:在江苏响水县及高邮县进行整群抽样,纳入调查人群1457例.调查方法采用问卷调查,问卷内容包括基本情况、家庭情况、饮水和个人习惯、饮食习惯、吸烟和饮酒习惯及既往病史,Hpylori检测采用血清HpyloriIgG抗体检查和13C呼气试验检查,如任何一项检测结果阳性则判Hpylori感染为阳性.结果:1371例完成了问卷调查及幽门螺杆菌检测,Hpylori总的感染率为62.07%,男女性别无差异,30-40岁感染率最高67.25%,但各年龄组间无显著差别.以年经济收入1000-4999元感染率为最低(53.49%),年经济收入愈高,Hpylori感染率也愈高.家庭人数增多Hpylori感染率显著增高,家庭中有10岁以下儿童Hpylori感染率偏高,小学教育程度时Hpylori感染率为最高(66.92%),总的趋势显示教育程度愈高,Hpylori感染率愈低.喝生水、茶杯用后不洗刷、合用茶杯、恶心、呕吐、嗳气者反而Hpylori感染率下降,饭前洗手、便后洗手、肥皂洗手反而Hpylori感染率升高.Hpylori感染率与每日食用米饭次数成正相关,而食用土豆则成负相关,与饮水水源、吸烟、饮酒无关.多因素Logistic回归分析,家庭经济收入与Hpylori感染成正相关,教育程度,茶杯用后洗刷与Hpylori感染成负相关.结论:我国胃癌高发区农村Hpylori感染、家庭人数、教育程度及家庭经济收入有关,并存在家庭聚集现象,有一定经济基础(5000元/年以上),受过一定教育(小学)的人易感染Hpylori.卫生习惯、饮水、饮食与Hpylori感染的关系有待进一步研究.

Epidemiological study of Helicobacter pylori infection and its risk factors in Jiangsu area

AIM: To investigate the infection status of Helicobacter pylori and its risk factors in Jiangsu area with a high incidence of gastric cancer. METHODS: A total of 1457 individuals from 3 rural villages in the northern area of Jiangsu province were included in this study, and data were collected by face-to-face interviews using a standard questionnaire, involving general con-ditions, family environment, drinking, personal habit, diet habit, smoking, alcohol drinking, and disease history. H pylori infection was assessed by detecting the serum antibodies of anti-H py- lori IgG or 13C-urea breath test. RESULTS: At last, the study was completed in 1371 individuals, and the total prevalence rate of H pylori infection was 62.07%. No association was found between infection and gender. The infection rate was different between different- age groups with no significance, and the highest rate was 67.25% (individuals of 30 to 40 years old). The prevalence of H pylori infection was in- creased significantly with the increase of annual family income, and the lowest rate was 53.49% (individuals with annual income of 1000 to 4999 RMB). H pylori infection was also related with the education level and size of household. H pylori infection rate was decreased signifi- cantly in subjects who drank raw water, drank water without washing cups, shared cups with others, had history of vomiting, belching, or nausea. However, the prevalence rate of H pylori infection was increased significantly in subjects who washed hands before meals and after def- ecation, using soaps. H pylori infection rate was positively correlated with the frequency of rice intake per day, but negatively correlated with the frequency of potato intake per day. There were no association between H pylori infection and source of drinking water, smoking or alco- hol drinking. Multivariate logistic regression analysis showed that H pylori infection was posi- tively associated with the family income, but negatively associated with education degree and washing cups after drinking. CONCLUSION: H pylori infection is strongly influenced by education level, size of household and annual family income in the rural area with high gastric cancer prevalence, and transmits within families. Further studies are needed on the association of H pylori infection with hygiene habits, source of drinking, and diet.