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来氟米特联合泼尼松治疗难治性肾病综合征的临床观察
引用本文:王静,常保超,杨萍,陈峥,史菲菲. 来氟米特联合泼尼松治疗难治性肾病综合征的临床观察[J]. 实用全科医学, 2011, 0(8): 1192-1193
作者姓名:王静  常保超  杨萍  陈峥  史菲菲
作者单位:安徽省蚌埠医学院第一附属医院肾内科;安徽省蚌埠医学院第一附属医院检验科;
摘    要:目的探讨来氟米特联合泼尼松治疗难治性肾病综合征的安全性和临床疗效。方法选取蚌医附院2007年1月-2010年12月收治的60例难治性肾病综合征患者,其中40例患者采用来氟米特联合泼尼松治疗,20例患者采用雷公藤多苷联合泼尼松治疗。观察两组患者治疗前及治疗后4周、8周、24周的24小时尿蛋白定量,血常规,肝肾功能及治疗期间的不良反应发生率。结果来氟米特联合泼尼松组治疗前后血清白蛋白上升和尿蛋白减少均显著优于雷公藤多苷联合泼尼松组(P〈0.05),治疗缓解率高于雷公藤多苷联合泼尼松组(P〈0.01),且不良反应发生率低,尤其对患者生育功能影响小,多数患者能够耐受治疗。结论来氟米特联合泼尼松能有效缓解难治性肾病综合征患者预后,临床治疗缓解率可能高于雷公藤多苷联合泼尼松治疗,但远期疗效有待观察。

关 键 词:来氟米特  难治性肾病综合征

The Clinical Observation the Treatment of Refractory Nephrotic Syndrome with Leflunomide
WANG Jing,CHANG Bao-chao,YANG Ping,et al.. The Clinical Observation the Treatment of Refractory Nephrotic Syndrome with Leflunomide[J]. Applied Journal Of General Practice, 2011, 0(8): 1192-1193
Authors:WANG Jing  CHANG Bao-chao  YANG Ping  et al.
Affiliation:WANG Jing,CHANG Bao-chao,YANG Ping,et al.Department of Nephrology,the First Affiliated Hospital of Bengbu Medical College,Bengbu 233004,Anhui,China
Abstract:Objective To investigate the safety and clinical efficacy of leflunomide and prednisone in the treatment of refractory nephrotic syndrome.Methods 60 patients in our hospital from January 2007 to December 2010 with refractory nephrotic syndrome were selected,40 patients were treated with leflunomide and prednisone,and 20 patients in the control group were treated with Tripterygium glycosides and prednisone.Patients were observed before and 4 weeks,8 weeks,24 weeks after treatment.24-hour urinary protein,bloo...
Keywords:Leflunomide  RNS  
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