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Immune reconstitution inflammatory syndrome in association with HIV/AIDS and tuberculosis: Views over hidden possibilities |
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| Authors: | Esaki Muthu Shankar Ramachandran Vignesh Kailapuri G Murugavel Pachamuthu Balakrishnan Ramalingam Sekar Charmaine AC Lloyd Suniti Solomon Nagalingeswaran Kumarasamy |
| Institution: | (1) Global AIDS Program, US Centers for Disease Control and Prevention, Entebbe, Uganda;(2) British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada;(3) Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada;(4) Institute for Global Health, University of California, San Francisco, San Francisco, California;(5) Medicins Sans Frontieres – Holland, Amsterdam, The Netherlands |
| Abstract: | BackgroundCD4+ T lymphocyte (CD4) cell count testing is the standard method for determining eligibility for antiretroviral therapy (ART), but is not widely available in sub-Saharan Africa. Total lymphocyte counts (TLCs) have not proven sufficiently accurate in identifying subjects with low CD4 counts. We developed clinical algorithms using TLCs, hemoglobin (Hb), and body mass index (BMI) to identify patients who require ART. |
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