表皮生长因子受体在膀胱移行细胞癌中表达的意义

目的 :探讨表皮生长因子受体 (EGFR)在膀胱移行细胞癌 (BTCC)中表达的意义。方法 :应用免疫组织化学ABC法 ,对 3 3例BTCC及 12例正常膀胱组织中EGFR抗原进行检测。结果 :EGFR在正常膀胱移行细胞中呈阴性表达 ,在BTCC组中呈阳性表达 ,且中 /强阳性表达率与不同病理分级、临床分期、单发与多发、复发与初发间均有显著性差异(P <0 0 5 )。结论 :EGFR的过表达与BTCC生物学行为密切相关 ,在BTCC发生发展过程中起重要作用

THE SIGNIFICANCE OF EPIDERMAL GROWTH FACTOR RECEPTOR IN HUMAN TRANSITION CELL CARCINOMA OF BLADDER

Objective:To evaluate the signifcance of epidermal growth factor receptor(EGFR) expression in human transitional cell carcinoma of bladder(BTCC).Methods:The expression of EGFR was detected by standard ABC immunohistochemical technique in 33 paraffin-embedded tissue specimens of BTCC compared with 12 normal ones.Results:All normal transitional cells were negatively stained and all neoplastic cells were positively stained .Fisher's accurate analysis showed that moderately or strongly positive espression of EGFR in tumor cells closely correlated with different pathological grades(P<0 05),clinical stages(P<0 05),number of lesions(P<0 05)and postoperative reccurance (P<0 05).Conclusion:It was suggested that over expression of EGFR closely correlated with biological behaviour of BTCC and it played a very important role on the process of occurence and progress.