前列腺素联合甲钴胺治疗糖尿病周围神经病变的临床疗效

目的观察前列腺素E1联合甲钴胺治疗糖尿病周围神经病变的临床疗效及其安全性。方法 96例糖尿病周围神经病变患者分为治疗组(n=55)及对照组(n=41),两组均给予胰岛素控制血糖,控制血压等基础治疗,治疗组同时给予前列腺E110μg/d静脉滴注及甲钴胺500μg/d肌肉注射治疗共4周,4周后改为甲钴胺500μg,3次/d口服继续治疗8周,于治疗前及治疗后分别测定双下肢运动神经传导速度、感觉神经传导速度及临床症状变化。结果治疗后患者周围神经病变如麻木、疼痛、感觉异常均有明显改善,神经传导速度有不同程度的提高,未出现明显不良反应。结论前列腺素E1及甲钴胺的联合应用对于糖尿病周围神经病变的疗效确切,临床治疗安全、可靠。

Prostaglandin combined with methylcobalamin in treatment of diabetic peripheral neuropathy

Objective To observe the clinical effect and safety of prostaglandin E1 combined with methylcobalamin in treating diabetic peripheral neuropathy.Methods Ninety-six diabetic peripheral neuropathy patients were divided into treatment group（n=55） and control group（n=41）,they were given insulin to control blood glucose,blood pressure control such treatment,the treatment group were given prostate E1 10 μg/d,intravenous drips and methylcobalamin 500 μg/d,intramuscular for 4 weeks.After four weeks,instead of a 500μg,methylcobalamin 3 times/day oral treatment in eight weeks.We measured the double lower motor and sensory nerve conduction velocity and observed clinical symptom before and after treatment.Results After the treatment,peripheral neuropathy symptoms such as pain and numbness,and paresthesia were obviously improved,nerve conduction velocity was improved to varying degrees,there was no obvious adverse reaction.Conclusion Prostaglandin E1 combined with methylcobalamin for diabetic peripheral neuropathy has clinical curative effect,and is safe and reliable.