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Catalepsy induced by intrastriatal injections of delta9-THC and 11-OH-delta9-THC in the rat
Authors:A L Gough  J E Olley
Affiliation:School of Pharmacology, University of Bradford. Bradford. BD7 IDP, U.K.
Abstract:
Intrastriatal injections of Δ9-THC and 1 l-hydroxy-Δ9-THC induced dose-dependent catalepsy in the rat, the parent compound being more potent than the metabolite. Catalepsy was not induced following intrapallidal injection of either drug. The results suggest that the caudate-putamen could be a “specific site” in the mediation of catalepsy induced by Δ9-THC.Intrastriatal amphetamine attenuated Δ9-THC-induced catalepsy whereas intrapallidal amphetamine potentiated the effect indicating a complex interaction with dopaminergic systems in the basal ganglia.Δ9-THC and the central cholinergic stimulant, RS-86 synergize on administration to either area indicating a possible cholinergic involvement in the phenomenon.
Keywords:
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