Validation of Addenbrooke's cognitive examination for detecting early dementia in a Japanese population |
| |
| Authors: | Hidenori Yoshida Seishi Terada Hajime Honda Toshie Ata Naoya Takeda Yuki Kishimoto Etsuko Oshima Takeshi Ishihara Shigetoshi Kuroda |
| |
| Affiliation: | 1. King''s College London, Department of Primary Care and Public Health Sciences, Capital House, 42, Weston Street, London SE1 3QD, United Kingdom;2. Department of Family Medicine, Faculty of Medical Sciences, University of Sri Jayewardenepura, Sri Lanka;1. Department of Neurology, The First Affiliated Hospital at Chongqing Medical University, 1, Yixue Road, Yuzhong District, Chongqing, 400016, China;2. Chongqing Key Laboratory of Neurobiology, Chongqing, China;3. Institute of Neuroscience, Chongqing Medical University, Chongqing, China;4. Department of Neurology, The Fifth People''s Hospital of Chongqing, Chongqing, China;1. District General Hospital of Vavuniya, Ministry of Health, Sri Lanka;2. Sri Lanka Cancer Research Group, Sri Lanka College of Oncologists, Sri Lanka;3. National Cancer Institute, Ministry of Health, Sri Lanka;4. Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom;6. The Christie NHS Foundation Trust, Manchester, United Kingdom;1. The George Institute for Global Health, University of New South Wales, Sydney, Australia;2. Clinical Trials Unit, Department of Pharmacology, Faculty of Medicine, University of Kelaniya, Sri Lanka;3. The George Institute for Global Health, University of New South Wales, Hyderabad, India;1. Schlegel-UW Research Institute for Ageing & School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada;2. School of Public Health and Health Systems, Faculty of Applied Health Sciences, University of Waterloo, Waterloo, Ontario, Canada;3. Michael G. DeGroote School of Medicine, Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada;4. University of Waterloo School of Pharmacy, 10 Victoria St S, Kitchener, Ontario N2G 1C5, Canada;5. Division of Cardiovascular Disease, University of Alabama at Birmingham, LHRB 310, 701 19th Street South, Birmingham, AL 35294, USA |
| |
| Abstract: | There is a clear need for brief, but sensitive and specific, cognitive screening instruments for dementia. We assessed the diagnostic accuracy of the Japanese version of Addenbrooke's Cognitive Examination (ACE) in identifying early dementia in comparison with the conventional Mini-Mental State Examination (MMSE). Standard tests for evaluating dementia screening tests were applied. A total of 201 subjects (Alzheimer's disease (AD) = 65, frontotemporal dementia (FTD) = 24, vascular dementia = 26, dementia with Lewy bodies = 11, mild cognitive impairment (MCI) = 13, and controls = 62) participated in this study. The reliability of the ACE was very good (alpha coefficient = 0.82). In our patient series, the sensitivity for diagnosing dementia with an ACE score of ≤ 74 was 0.889 with a specificity of 0.987, and the sensitivity of an ACE score of ≤ 80 was 0.984 with a specificity of 0.867. The Japanese version of the ACE is a very accurate instrument for the detection of early dementia, and should be widely used in clinical practice. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
