| 家兔血浆中尼群地平的气相色谱测定法 |
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| 引用本文： | 王云志,查建蓬,刘伟娜,刘慧敏,高秀强,杜丽华. 家兔血浆中尼群地平的气相色谱测定法[J]. 河北医科大学学报, 1992, 0(4) |
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| 作者姓名： | 王云志 查建蓬 刘伟娜 刘慧敏 高秀强 杜丽华 |
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| 作者单位： | 河北医学院分析化学教研室，河北医学院分析化学教研室，河北医学院分析化学教研室，河北医学院基础医学研究所理化室，河北医学院基础医学研究所理化室，河北医学院基础医学研究所理化室 药学系85级实习生，药学系85级实习生 |
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| 摘 要： | 尼群地平是一种新型的钙拮抗剂,临床上用于治疗高血压。在碱性条件下用乙醚/环己烷(3/7)混合溶剂从血浆中提取尼群地平,在气相色谱上直接进样(OV—17柱,电子捕获检测器)。在3—30ng/ml浓度范围内,标准曲线呈线性。对家兔的药代动力学参数一并报道。
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| 关 键 词： | 尼群地平 气相色谱 药代动力学 |
DETERMINATION OF NITRENDIPINE IN RABBIT PLASMA BY GAS CHROMATOGRAPHY |
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| Wang Yunzhi Zha Jianpeng Liu Weina. DETERMINATION OF NITRENDIPINE IN RABBIT PLASMA BY GAS CHROMATOGRAPHY[J]. Journal of Hebei Medical University, 1992, 0(4) |
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| Authors: | Wang Yunzhi Zha Jianpeng Liu Weina |
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| Affiliation: | Wang Yunzhi Zha Jianpeng Liu Weina Department of Analytical Chemistry Liu Huimin Gao Xiuqiang Du Lihua Institute of Basic Medicine |
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| Abstract: | Nitreadipine, a calcium antagonist, now widely used in the treatment of hypertension, was extracted from plasma under basic conditions with ether/hexane solvent (3/7). An aliquot of the extract is injected directly into a gas chromatography equipped with OV-17 column and an electon capture detector. The standard curve is linear between 3-30ng/ml. Pharmacokinetic parameters obtained in the intravenous administration of four rabbits are reported. |
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| Keywords: | Nitrendipine gas chromatography pharmacokinetic parameter |
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