左卡尼汀对糖尿病心力衰竭患者的治疗作用

目的探讨左卡尼汀对糖尿病心力衰竭患者的治疗效果及其对血糖、血脂的影响。方法将90例糖尿病心功能不全患者随机分为两组:对照组44例给予常规治疗,左卡尼汀组46例在常规治疗基础上加用左卡尼汀2.0g1次/d静脉滴注。治疗3周后比较两组心功能及血糖、血脂变化。结果左卡尼汀组治疗后射血分数明显高于对照组(36.7±3.6vs31.7±4.2,P<0.05),左室舒张末期内径、左室收缩末期内径明显小于对照组(40.6±1.6vs44.9±2.7、56.2±4.0vs61.3±2.9,P<0.05),且空腹血糖也较对照组明显降低(6.05±2.13vs7.14±3.16,P<0.05)。结论左卡尼治疗糖尿病心力衰竭不仅能改善患者心功能,提高运动耐力,而且还可降低血糖,并能调节血脂。

Therapeutic effects of L-carnitine on heart failure in patients with diabetes mellitus

Objective To investigate the efficacy of L-carnitine on heart failure(HF),and its influence on blood glucose and lipid metabolism in patients with diabetes mellitus.Methods 90 HF patients with diabetes mellitus were divided randomly into 2 groups. 44 cases as controls,who were given routine treatment;46 as L-carnitine group cases,who were also given L-carnitine 2.0 g qd besides routine treatment for 3 weeks.The heart function was evaluated by heart function improvement,echocardiography and 6 minute walk distance,and blood glucose,blood lipid were compared also.Results L-carnitine group had a higher effective ratio than control group(95.7% VS 63.6%,P<0.05),get a more LVEF and 6 minute walk distance than control group(P<0.05),and effectly reduced LVED and LVES(P<0.05),L-carnitine group had less free blood glucose and TC,TG.Conclusion L-carnitine can improve the heart function by enhancing the heart energy metabolism.improve blood glucose metabolism. It is a safe and effective adjuvant drug for heart failure of patients with diabetes.