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| 哒唑氧苯的合成及其抗血栓作用的研究 | |
| 引用本文： | 魏金友 万维勤. 哒唑氧苯的合成及其抗血栓作用的研究[J]. 中国医药工业杂志, 1990, 21(9): 385-387 |
| 作者姓名： | 魏金友 万维勤 |
| 作者单位： | 第二军医大学药学院朝晖药厂，第二军医大学药物化学教研室 上海 200433 |
| 摘 要： | 选择性血栓素A_2合成酶抑制剂哒唑氧苯,由4-(2-氯乙氧基)苯甲酸乙酯与咪唑经相转移催化缩合反应而制得。药理实验结果表明该药有抑制大鼠中性粒细胞释放TXB_2和促使牛主动脉内皮细胞cAMP水平升高的作用。 |
| 关 键 词： | 哒唑氧苯 合成 抗血栓 |
SYNTHESIS AND ANTITHROMBOTIC EFFECT OF DAZOXIBEN |
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| WEI Jin-You,WAN Wei-Qin Zhaohui Pharmaceutical Factory,College of Pharmacy,Second Military Medical University,Shanghai. SYNTHESIS AND ANTITHROMBOTIC EFFECT OF DAZOXIBEN[J]. , 1990, 21(9): 385-387 | |
| Authors: | WEI Jin-You WAN Wei-Qin Zhaohui Pharmaceutical Factory College of Pharmacy Second Military Medical University Shanghai |
| Affiliation: | WEI Jin-You,WAN Wei-Qin Zhaohui Pharmaceutical Factory,College of Pharmacy,Second Military Medical University,Shanghai 200433 |
| Abstract: | Dazoxiben was synthesized with phase transfer catalytic alkylation between ethyl 4-(2-chlorothoxy) benzoate and imidazole. Pharmacological tests showed that dazoxiben inhibited the production of TXB_2from rat neutrophils and increased intracellular level of cAMP in bovine aorticendothelial cells. |
| Keywords: | dazoxiben phase transfer catalysis antithrombotic effect |
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