| 狼疮性肾炎抗活化蛋白C的测定及意义 |
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| 引用本文： | 汪国生,李向培,吴竟生,周志中,厉小梅,陈育华,徐修才. 狼疮性肾炎抗活化蛋白C的测定及意义[J]. 安徽医学, 2001, 22(4): 1-3 |
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| 作者姓名： | 汪国生 李向培 吴竟生 周志中 厉小梅 陈育华 徐修才 |
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| 作者单位： | 230001,合肥,安徽省立医院风湿科;230001,合肥,安徽省立医院中心实验室;230001 合肥 安徽省立医院B超室 |
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| 基金项目： | 安徽省自然科学基金;98452234; |
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| 摘 要： | 目的 :探讨抗磷脂抗体和抗活化蛋白C(APCR)与狼疮性肾炎 (LN)的关系及APCR的可能形成原因。方法 :检测 33例LN和 37例无LN的系统性红班狼疮 (NLN) ,ELISA检测ACA -IgG、IgM、IgA、PTT -LA检测LA ,APTT±APC检测APCR。结果 :LN组APCR阳性率 5 7 6% ,明显高于NLN组 ( 32 4% ) ;LN组ACA(IgG、IgM )阳性率 42 4% ,明显高于NLN组 ( 18 9% ) ;APCR和IgG -ACA同时阳性LN的发生率 ( 7/ 7)明显高于APCR阳性而IgG -ACA阴性者( 12 / 2 4)。结论 :APCR和ACA在LN有较高的发生率 ,ACA引起的获得性APCR可能是LN的发病机制之一。
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| 关 键 词： | 狼疮性肾炎 抗活化蛋白C 抗磷脂抗体 |
| 修稿时间： | 2001-03-07 |
The detection of activated protein C and in lupus nephritis its significance |
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| Wang Guosheng,Li Xiangpei,Wu jingsheng,et al.. The detection of activated protein C and in lupus nephritis its significance[J]. Anhui Medical Journal, 2001, 22(4): 1-3 |
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| Authors: | Wang Guosheng Li Xiangpei Wu jingsheng et al. |
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| Affiliation: | Wang Guosheng,Li Xiangpei,Wu jingsheng,et al. Anhui Provincial Hospital,Hefei 230001 |
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| Abstract: | Objective:To explore the relationship between activated protein C(APCR),antiphospholipid antibodies and lupus nephritis(LN) and the possible reasons for APCR.Methods:APCR,ACA(lgG,lgM,lgA),LA,were measured with APTT±APC,ELISA,PTT-LA methods respectively in 33 LN patients and 37 SLE patients without LN(NLN).Results:The postive rates of APCR and ACA(IgG,IgM)in LN group were 57.6% and 42.4% respectively,which were significantly higher than that of NLN group(32.4% and 18.9% respectively).LN was more common in APCR and ACA-IgG positve patients(7/7) than in APCR positive but ACA-lgG negative patients (12/24).Conclusion:There were high prevalence of APCR and ACA in lupus nephritis.The acquired APCR induced by ACA may play an important role in LN's pathogenic mechanisms. |
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| Keywords: | Lupus nephritis Activated protein C resistance Antiphospholipid antibody |
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