临床肠内营养支持对老年慢性阻塞性肺病患者心肺功能影响的干预研究

目的探讨肠内营养对老年慢性阻塞性肺病(chronic obstructive pulmonary disease,COPD)患者心肺功能的影响。方法选择老年COPD稳定期患者58例,常规治疗基础上随机分为2组,其中治疗组29例(肠内营养),对照组29例(自由饮食)。治疗前后检测各项营养指标(血清总蛋白、白蛋白、前白蛋白)、LVEF、肺功能[第一秒用力呼气容积(FEV1),用力肺活量(FVC)]。结果治疗组治疗后体质量指数、血清总蛋白、白蛋白、前白蛋白水平较治疗前明显升高,而对照组以上各项指标改善不明显。治疗组治疗后体质量指数、血清总蛋白、白蛋白、前白蛋白水平较对照组明显改善,差异有统计学意义(P<0.05)。治疗组治疗后LVEF[(48.98±6.38)%vs(42.38±5.98)%,(42.73±5.34)%]、FVC[(2.98±0.38)Lvs(2.75±0.31)L,(2.76±0.34)L]、FEV1[(2.06±0.87)Lvs(1.78±0.72)L,(1.92±0.90)L]、FEV1/FVC[(78.36±12.32)vs(70.65±12.28),(71.23±12.55)]较治疗前和对照组明显改善,差异有统计学意义(P<0.05)。结论老年COPD患者,在常规治疗的同时给予肠内营养治疗,可以改善患者营养状况,进一步改善患者心肺功能,缩短住院时间。

Effect of enteral nutrition on cardio-pulmonary function in elderly patients with chronic obstructive pulmonary disease

Objective To study the effect of enteral nutrition on cardio-pulmonary function in elderly patients with chronic obstructive pulmonary disease(COPD).Methods Fifty-eight elderly COPD patients were randomly divided into treatment group(enteral nutrition group,n=29)and control group(free diet group,n=29).Their nutrition parameters(BMI,serum total protein,albumin and prealbumin),LVEF and pulmonary function(FEV1,FVC,FEV1/FVC)were assayed before and after treatment.Results The BMI,serum levels of total protein,albumin and prealbumin were significantly higher in treatment group after treatment than before treatment(P< 0.05).However,no significant difference was observed in these parameters in control group after treatment.The LVEF,FVC,FEV1and FEV1/FVC were significantly higher in treatment group than in control group after treatment(P<0.05).Conclusion Enteral nutrition in combination with conventional treatment can improve the nutrition and cardio-pulmonary function in elderly COPD patients,thus shortening their hospital stay time.