1 837例区域淋巴结转移的乳腺癌患者临床病理多因素预后分析

目的 对区域淋巴结转移的乳腺癌患者进行临床病理多因素预后分析。方法 选择２０个可能对区域淋巴结转移的乳腺癌患者预后产生影响的非重复特征的临床病理因素,通过计算机,采用累计生存率及ＣＯＸ多因素分析模型,进行单因素及多因素的预后分析。结果 在选取的２０个因素中,月经状况、初潮年龄、病程、活检方式、术后内分泌治疗、活检时间与生存率相关,但多因素分析则无关;而妊娠次数、肿瘤大小、手术方式、内乳淋巴结情况、

A multivaviate analysis of prognosis in 1837 breast cancer patients with positive regional lymph nodes impact of clinilcal pathological factors

Objective To study the prognosis of breast cancer patients. with regional lymph node metartasis. Methods The data were analyzed in 1837 consecutive breast cancer patients, with positive regional lymph node, twenty individual variables were evaluated statistically using the life table method for univariate analysis and the cumulative survival rate by the computer' Cox multivariate analysis model. Results In univariate analysis, menopausal status, age of menarche, duration before diagnosis, type and time of biopsy, postoperative endocrine therapy predicated disease free period and overall survival. In multivariate analysis, number of pregnancy, tumor size, type of surgery, intramammary lymph node status, number of positive axillary node, skin status, pathologic, pattern postoperative chemotherapy, pre- and post operative radiotherapy were verified to be independent prognostic factors. Conclusion The progosis of patients with locally advanced breast cancer was miserable. Selective extending radical mastecomy could not only provide intramammary lymph node status to predict survival, but also improve the survival rate. Postoperative chemotherapy should be used for patients with positive node to improve survival rate, The role of selective endocrinel therapy to patients with positive lymph node remains to be investigated.