| 复方中药对多囊卵巢综合征模型大鼠血清性激素、瘦素水平的影响 |
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| 引用本文： | 邓阿黎,周忠明,向楠,姜惠中,张亚兵,金晶,余念,陈露.复方中药对多囊卵巢综合征模型大鼠血清性激素、瘦素水平的影响[J].中国临床药理学与治疗学,2008,13(10). |
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| 作者姓名： | 邓阿黎 周忠明 向楠 姜惠中 张亚兵 金晶 余念 陈露 |
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| 作者单位： | 1. 湖北中医学院附属医院妇产科,武汉,430061,湖北
2. 武汉大学中南医院中医科,武汉,430070,湖北 |
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| 基金项目： | 武汉市科技厅科技攻关项目 |
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| 摘 要： | 目的:观察多囊卵巢综合征(PCOS)模型大鼠血清性激素T、FSH、LH及瘦素(Leptin)水平的变化,探讨复方中药对PCOS模型大鼠生殖内分泌系统的影响。方法:本实验采用Poresky法进行造模,并分别以中药、西药(罗格列酮)、中西药联合用药治疗,观察治疗后大鼠体重、血清性激素及Leptin水平的变化,并进行Leptin水平与FSH、LH、LH/FSH、T、WEIGHT的相关分析。结果:复方中药能降低血清T、LH、Leptin水平及LH/FSH比值,且血清Leptin水平与LH、T呈正相关。结论:复方中药能改善PCOS模型大鼠的生殖内分泌功能,降低血清Leptin水平。
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| 关 键 词： | 中药 多囊卵巢综合征 T FSH LH 瘦素 |
Influence of traditional Chinese medicine on PCOS rat model serum sex hormone T,FSH,LH,and Leptin |
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| DENG A-li,ZHOU Zhong-ming,XIANG Nan,JIANG Hui-zhong,ZHANG Ya-bing,JING Jing,YU Nian,CHEN Lu.Influence of traditional Chinese medicine on PCOS rat model serum sex hormone T,FSH,LH,and Leptin[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2008,13(10). |
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| Authors: | DENG A-li ZHOU Zhong-ming XIANG Nan JIANG Hui-zhong ZHANG Ya-bing JING Jing YU Nian CHEN Lu |
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| Institution: | 1Department of Gynaecology and Obstetrics Affiliated Hospital; Hubei College of Traditional Chinese Medicine; Wuhan 430061; Hubei; China; 2Department of Traditional Chinese Medicine Zhongnan Hospital of Wuhan University; Wuhan 430070; |
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| Abstract: | AIM:To observe the changes of serum sex hormone T,FSH,LH and Leptin,and explore the influence of traditonal Chinese medicine complex on the reproduction endocrine system in PCOS rat model.METHODS:PCOS rat model was established by Poresky method,the changes of the rats weight,serum sex hormone T,FSH,LH and Leptin were observed after the treatment with traditional Chinese medicine,western medicine(rosiglitazone),united medication,respectively,and the correlations of serum Leptin levels with FSH,LH,LH/FSH,T,Weight were analyzed.RESULTS:The traditional Chinese medicine group could decrease serum sex hormone T,LH,Leptin level and the LH/FSH,Leptin level and LH,T were positive correlated in model rats.CONCLUSION:The traditional Chinese medicine can improve reproduction endocrine system functoins and decrease serum Leptin levels on PCOS rat model. |
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| Keywords: | traditional Chinese medicine PCOS T FSH LH Leptin |
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