IGF-1和其受体IGF-1R在前列腺癌和良性前列腺增生组织中的表达

目的：探讨胰岛素样生长因子l（insulin—like growth factor1。IGF-1）及其受体IGF-1R（insulin—like growth factor-1receptor,IGF11R）在前列腺癌（prostatecancer,PCa）发生和发展中的生物学作用。方法：对26例PCa和30例良性前列腺增生（benign prostatic hyperplasia，BPH）标本进行石蜡包埋免疫组化染色，分析IGF-1和IGF-1R在PCa和BPH组织中的表达情况及表达强度。结果：IGF-1和IGF-1R在前列腺癌组织中的表达明显增高（P〈0．05），在PCa组织中阳性部位主要位于PCa细胞。结论：IGF-1和IGF-1R与PCa的发生发展可能有关．以IGF-1和IGF-1R为共同靶点有望成为前列腺癌新的治疗途径。

Expression of IGF-1 and IGF-1R in prostate cancer and benign prostatic hyperplasia

Objective： To study the relationship between the expression of insulin-like growth factor 1（IGF-1） and insulin- like growth factor-1 receptor （IGF-1R）and prostate cancer. Methods： A total of 26 specimens of PCa and 30 of BPH tissues were examined by means of immunohistochemistry for the expression of IGF-1 and IGF-1R. Results： the expression of IGF-1 and IGF-1R were stronger in PCa, positive staining mostly in cancer cells in PCa. Conclusion： IGF-1 and IGF- 1R may be involved in the development and progression of PCa. They promise to be a new target in the treatment of PCa.