Na-dependent Li-transport in primary nerve cell cultures |
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Authors: | I Szentistványi Z Janka F Joó A Rimanóczy A Juhász L Latzkovits |
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Affiliation: | 1. Department of Neurology and Psychiatry, University Medical School, Hungary;1. Institute of Biophysics, Biological Research Center, Szeged Hungary |
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Abstract: | Primary cultures from chick embryonic brain were used to study the steady state distribution of lithium. The intra/extracellular Li+ ratio decreased by enhancing the external Na+ concentration. Ouabain did not influence this unequality. A phloretin-sensitive component was revealed in the Li uptake at low Na+ concentration. The findings might suggest the existence of a Na+-dependent Li+ countertransport system in these brain cell cultures. |
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