Ghrelin和MMP-9在结直肠癌组织中的表达及意义

目的：观察生长激素释放肤（growth hormone releasing peptide，Ghrelin）和基质金属蛋白酶-9（Matrix metalloproteinases，MMP-9）在结直肠癌组织中的表达水平及意义。方法：应用免疫组织化学方法检测Ghrelin和MMP-9在67例结直肠癌组织及62例癌旁正常黏膜组织中的表达，分析Ghrelin和MMP-9与结直肠癌临床病理特征的关系及两者的相关性。结果：Ghrelin在结直肠癌组织中的阳性表达率为59．70％，高于癌旁正常黏膜组织（24．39％，P〈0．05）；MMP-9在结直肠癌组织中的阳性表达率为83．58％，显著高于癌旁正常黏膜组织（18．39％，P〈0．05）；Ghrelin和MMP-9的高表达与肿瘤浸润深度、分化程度、淋巴结转移和肝转移相关（P〈0．05）；Ghrelin与MMP-9的阳性表达呈正相关（K=0．832，P〈0．001）。结论：Ghrelin和MMP-9表达升高可能与结直肠癌的恶性程度相关，联合检测Ghrelin和MMP-9可能对结直肠癌恶性程度及患者预后评估具有重要意义。

The relationship between expression of Ghrelin and MMP-9 in colorectal cancer

Objective：To investigate the correlation between the Ghrelin and MMP-9 in colorectal cancer tissue. Methods： Immunohistoehemieal staining was performed to detect the expression of Ghrelin and MMP-9 in the tumor tissues of 67 patients and in the adjacent mucosal tissues of 62 cases. And statistical analysis technique was used to investigate the relation between their expression and the elinicopathologic parameters of the patients, and the relationship between the expression of Ghrelin and MMP-9. Results：The total positive rate of Ghrelin expression in the carcinoma tissues was 59.70%, significantly highter than that in the adjacent mueosal tissues（24.39%,P〈0.05 ）. The positive rate of MMP-9 expression in the carcinoma tissues was 83.58%, significantly bighter than that in the adjacent mueosal tissues（18.39%,P〈0.05）. The expression of Ghrelin and MMP-9 were significantly correlated with invasion depth, differentiation, lymph node metastasis and hepatic metastasis （P〈0.05）. The positive expression of Ghrelin was consistent with the positive expression of MMP-9 （K=0.832,P〈0.001）. Conclusion：Expressions of Ghrelin and MMP-9 are closely related to the degree of malignancy of coloreetal cancer, and their combination may be an important indicator to evaluate the malignant degree and prognosis of the eoloreetal cancer.