载脂蛋白E及其基因敲除小鼠的研究进展

载脂蛋白E是血浆脂蛋白的重要组成成分,在脂质代谢中发挥着重要的作用。它的缺失或者变异都会引起体内的代谢异常或者组织器官的功能障碍,从而导致一系列的疾病和并发症。载脂蛋白E基因敲除小鼠问世以来,它给研究载脂蛋白E的功能及其在各种相关疾病当中的作用提供了广阔的平台。近年来,载脂蛋白E基因小鼠已成为动脉粥样硬化相关研究中最受欢迎的动物模型之一。

ApoE and ApoE Knockout Mice

ApoE is an important component of plasma lipoproteins,and plays significant roles in lipoprotein metabolism.The absence or mutation of apoE may give rise to abnormal metabolism in vivo and dysfunction of organs,and then lead to a series of diseases and complications.Since the generation of apoE knockout mice,they have offered a wonderful base to study the functions of apoE and its roles in various related disease.Recently,the apoE knockout mice have been regarded as one of most popular animal models in experimental atherosclerosis research.