建立减压病动物模型的研究

目的为深入研究减压病（DCS）提供复现不同种类动物DCS的基本实验方法，掌握不同种类动物DCS发病的共性并明确减压致病的靶器官。方法使11种动物在不同压力、暴露不同时间，以不同加、减压速率将动物减至常压后，心前区Doppler间断监测气泡音，观察动物发病过程，对一些动物进行球结膜显微和病理学检查。结果所用动物减压后心前区监测到Ⅳ级气泡音，75％～100％发生不同程度的DCS，DCS动物血管痉挛，功能障碍，血管内皮肿胀，出血。结论11种动物都能复现出DCS。不同种类动物DCS发病规律相同，血管是减压致病的靶器官。

Study on Animal Models of Decompression Sickness

Objective To study the profiles of decompression sickness(DCS) in various kinds of animals and to find out the target organ of decompression sickness by providing a basic experimental method for establishing animal models.Method Eleven kinds of animals were exposed to different pressures for different times at different compression/decompression rates.They were monitored at the precordial regions with Doppler flow meter for bubble sounds after decompression to normal pressure,to obtain a record about the developing course of the DCS.Pathological examinations of the bulbar conjunctiva were also made. Result Bubble sound of grade IV were recorded at the precordial regions after decompression.Among them,75%~100% incurred DCS with a diverse extent. Animals developed DCS showed vascular spasm,dysfunction and endothelial tumefaction.Conclusion Each of the 11 kinds of animals can serve as a model of DCS and the processes of development of DCS in various animals are similar.Blood vessels are the target organs of decompression sickness.