中西医药结合治疗2型糖尿病的临床研究

目的观察中西医药结合对2型糖尿病（DM）血糖及胰岛β细胞功能相关指标的影响。方法60例使用口服降糖西药而血糖控制不佳的2型DM患者分为2组，对照组30例患者继续原治疗方案，试验组30例患者在原治疗方案基础上再加用金芪降糖片，每次8-10片，3次／d。12周后观察血糖、胰岛素、C肽、糖化血红蛋白（HbA1C）及血脂的变化；同时以HOMA模型计算胰岛素分泌指数（Homa-β）、Homa胰岛素抵抗指数（Homa-IR）。结果12周后，试验组空腹血糖、餐后2h血糖、HbA1C和总胆固醇、三酰甘油显著下降，对照组无明显变化，两组差异有非常显著意义（P〈0.01）；空腹胰岛素、C肽无明显变化（P〉0.05），餐后2h胰岛素、C肽升高（P〈0.01），且两组差异有统计学意义（P〈0.01）Homa-β升了10±0.6，Homa-IR下降0.7±0.5（P〈0.01）结论对于2型糖尿病患者辩证为气阴两虚火旺者，在应用西药降血糖时加用中成药金芪降糖片，还能改善胰岛B细胞功能。

The clinical research on treatment of type 2 diabetes mellitus by western medicine combining with traditional Chinese medicine

Objective To investigate the effects of western medicine combining with traditional Chinese medicine on patients with T2DM and function of islet β cell. Methods 60 Type 2 diabetic patients with poor western medicine controlled Blood glucose were randomly divided into 2 groups, the control group and the trial group. 30 patients from the control group continue the original treatment. The trial group added Jinqijiangtangpian on the basis of the original treatment,8-10 tablets each time, threes times a day. Blood glucose , C peptide , HbA1C and blood fat were measured after 12 weeks and HOMA-β as well as Homa-IR were calculated by HOMA model. Results After 12 weeks , FBG ,2 h PBG , HbA1C and TC and TG were significantly lower than the control group （P〈0.01）. No difference were found in fasting insulin and C peptide （ P 〉 0.05）. 2 h postprandial insulin and C peptide rose （P 〈 0.01）. Homa-β rose by 10±0.6. Homa-IR declined by 0.7±0.5 （P 〈 0.01）. Conclusions To the patients with deficiency of both vital energy and yin, treatment of the Chinese formulated product Jinqijiangtangpian on the basis of western medicine can improve the islet β-cell function.