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| CD40/CD40L系统与动脉粥样硬化和脑梗死的关系 | |
| 引用本文： | 凌启节,储照虎. CD40/CD40L系统与动脉粥样硬化和脑梗死的关系[J]. 国际脑血管病杂志, 2010, 18(8). DOI: 10.3760/cma.j.issn.1673-4165.2010.08.012 |
| 作者姓名： | 凌启节 储照虎 |
| 作者单位： | 皖南医学院弋矶山医院神经内科,芜湖,241001 |
| 摘 要： | 脑动脉粥样硬化是导致脑梗死的主要原因.CD40/CD40L的过度表达会激发免疫和炎症反应,导致粥样斑块内局部炎症细胞浸润,促发斑块破裂,进而发生脑梗死.近年来的研究表明,CD40L与脑梗死体积和严重程度相关.因此,检测CD40L可作为判断脑梗死严重程度的一项指标,用以指导临床治疗. |
| 关 键 词： | CD40抗原 CD40配体 动脉粥样硬化 脑梗死 |
CD40/CD40L system and atherosclerosis and cerebral infarction |
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| LING Qi-jie,CHU Zhao-hu. CD40/CD40L system and atherosclerosis and cerebral infarction[J]. International Journal of Cerebrovascular Diseases, 2010, 18(8). DOI: 10.3760/cma.j.issn.1673-4165.2010.08.012 | |
| Authors: | LING Qi-jie CHU Zhao-hu |
| Abstract: | Cerebral artery atherosclerosis is the main reason leading to cerebral infarction. CD40/CD40L overexpression will stimulate the immune and inflammatory responses,leading to local inflammatory cell infiltration within the atherosclerotic plaque, triggering plaque rupture, and thus causing cerebral infarction. Studies have suggested that that CD40L is associated with the severity of cerebral infarction, Therefore, clinical detection of CD40L can be used as an indicator for identifying the severity of cerebral infarction to guide clinical treatment. |
| Keywords: | Antigens,CD40 CD40 ligand Atherosclerosis Brain infarction |
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