鹿茸醇提物对心肌梗死模型大鼠心肌损伤的保护作用及对血浆内皮素含量的影响

目的观察鹿茸醇提物对心肌梗死模型大鼠心肌损伤的保护作用。方法采用结扎冠脉造成大鼠急性心肌缺血的损伤模型,观察鹿茸醇提物对心肌梗死模型心肌损伤急性期后大鼠心电图(ECG)、心肌梗死面积(MIS)、内皮素(ET)等指标的影响。结果鹿茸醇提物对大鼠心肌缺血程度(Σ-ST)有明显的改善作用,能减小MIS,降低ET水平。结论鹿茸醇提物对心肌梗死模型大鼠心肌损伤有一定的保护作用,可能与降低心肌损伤时ET含量有关。

Protective Effect of Alcholic Extractive of Cornu Cervi against Myocardial Damage of Acute Myocardial Infarction Model Rats and Influence on plasma ET

Objective To observe the protective effect of alcholic extractive of Cornu Cervi against the myocardial damage of acute myocardial infarction model rats. Methods The myocardial ischemia rats model was made by ligaturing their coronary attery, and the indexes including electrocardiogram, the area of acute myocardial infarction and ET of acute myocardial infarction model rats were observed after the acute period of myocardial damage. Results The alcoholic extractive of Cornu Cervi could obviously improve the degree of myocardial ischemia, reduce the area of myocardial ischemia, and lessen the level of ET. Conclusion The alcoholic extractive of Cornu Cervi could protect the myocardial against the damage of acute myocardial infarction model rats in some degree. The mechanism may be related to the reduction of value of ET of myocardial damage.