Functional interleukin-17 receptor A is expressed in central nervous system glia and upregulated in experimental autoimmune encephalomyelitis |
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| Authors: | Jayasri Das Sarma Bogoljub Ciric Ryan Marek Sanjoy Sadhukhan Michael L Caruso Jasmine Shafagh Denise C Fitzgerald Kenneth S Shindler AM Rostami |
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| Affiliation: | (1) Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA;(2) Department of Ophthalmology, University of Pennsylvania, Scheie Eye Institute and FM Kirby Center for Molecular Ophthalmology, Philadelphia, PA 19104, USA;(3) Indian Institute of Science Education and Research-Kolkata (IISER-K), HC-VII, Sector-III, Salt Lake, Kolkata, 700-106, India |
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| Abstract: | ![]()
Background Interleukin-17A (IL-17A) is the founding member of a novel family of inflammatory cytokines that plays a critical role in the pathogenesis of many autoimmune diseases, including multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). IL-17A signals through its receptor, IL-17RA, which is expressed in many peripheral tissues; however, expression of IL-17RA in the central nervous system (CNS) and its role in CNS inflammation are not well understood. |
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