血清HE4在卵巢癌中的表达及其诊断价值

目的:探讨测定血清人附睾蛋白4(Human epididymis protein4,HE4)水平对卵巢癌的诊断价值.方法:收集海南医学院附属医院妇科2010年5月～2011年2月收治经病理检查确诊的盆腔肿物患者 160 例,采用酶联免疫吸附试验方法(EL,ISA)检测血清HE4和CAl25在卵巢癌组、卵巢良性肿瘤组、盆...

Expression and predictive value of HE4 level in diagnosis of ovarian carcinoma

Objective：To explore the expression and the predictive value of the serum human epididymis protein 4（HE4） level in the diagnosis of ovarian carcinoma.Methods：Data of 160 cases that were diagnosed and confirmed as pelvic mass in our hospital during May 2010 and June 2011 were analyzed,including benign and malignant ovarian tumor and other benign diseases.HE4 and CA125 levels were measured and compared by enzyme-linked immune sorbent assay（ELISA） among these patients.Results：1.HE4 and CA125 levels were significantly higher in patients with ovarian cancer than that in patients with benign tumor or other benign pelvic masses（P=0.000）,but no significant difference was observed between the latter two groups.2.For the 18 malignant ovarian tumor cases,positive rate of serum HE4 and CA125 were 50.00%（9/18）、33.33%（6/18） respectively;positive rate for both serum HE4 and CA125 was 33.33%（6/18）.Conclusions：Serum HE4 level is increased in malignant ovarian tumor thus it＇s helpful for the differentiation of malignant and benign ovarian tumor.