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Intraocular microsporidiosis due to Encephalitozoon cuniculi in a patient with idiopathic CD4+ T-lymphocytopenia |
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| Authors: | Kodjikian Laurent Garweg Justus G Nguyen Mai Schaffner Thomas Deplazese Peter Zimmerli Stefan |
| Affiliation: | aDepartment of Ophthalmology, University Hospital, Bern, Switzerland bDepartment of Ophthalmology, Croix-Rousse Hospital, EA 3090, University of Lyon I Claude Bernard, 103 Grande rue de la Croix-Rousse, Lyon F-69004, France cInstitute for Infectious Diseases, University of Bern, Switzerland dInstitute for Pathology, University of Bern, Switzerland eInstitute of Parasitology, University of Zurich, Switzerland |
| Abstract: | Encephalitozoon cuniculi was documented to cause disseminated microsporidial infection including an iris tumor and endophthalmitis in an adolescent with idiopathic CD4+ T-lymphocytopenia. The diagnosis was established by microscopic, serologic and molecular methods. E. cuniculi (rabbit strain) was identified from the iris tumor, as well as from urine, conjunctival, corneal, and nasal swabs. Treatment with oral albendazole led to rapid improvement. This case raises the possibility of disseminated microsporidial infection in the context of idiopathic CD4+ T-lymphocytopenia and possibly advanced human immunodeficiency virus (HIV) infection, and above all the possibility of intraocular infection with E. cuniculi in humans. |
| Keywords: | Encephalitozoon cuniculi Disseminated microsporidiosis Iris tumor Endophthalmitis Idiopathic CD4+ T-lymphocytopenia |
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