|
|||||
|
|
| 乳腺癌的抗血管生成及治疗药物研究进展 | |
| 引用本文： | 汤美春,陆涛. 乳腺癌的抗血管生成及治疗药物研究进展[J]. 海峡药学, 2006, 18(4): 4-7 |
| 作者姓名： | 汤美春 陆涛 |
| 作者单位： | 中国药科大学有机化学教研室,南京,210038;中国药科大学有机化学教研室,南京,210038 |
| 摘 要： | 肿瘤血管生成是一个多步骤过程,它导致已有的血管系统中生成新的血管,它对转移瘤的生长、转移和发展起关键作用。实验和临床数据证明,乳腺癌是一种血管生成依赖型疾病,而血管内皮生长因子(VEGF)家族的高表达和选择性内皮生长因子起关键作用,临床前研究表明血管生成启动发生在乳腺癌发展多步过程的早期。从肿瘤发展的生物学分子通道的靶向治疗已成为一种新的治疗策略,其目的是控制肿瘤的生长。 |
| 关 键 词： | 乳腺癌 血管生成 抗血管生成 |
| 文章编号： | 1006-3765（2006）04-0004-04 |
Antiangiogenic and compounds in Breast Cancer |
|
| TANG Mei-chun,LU-Tao. Antiangiogenic and compounds in Breast Cancer[J]. Strait Pharmaceutical Journal, 2006, 18(4): 4-7 | |
| Authors: | TANG Mei-chun LU-Tao |
| Affiliation: | Department of Organic Chemistry, China Pharmaceutical University, Nanjing, 2]0038, China |
| Abstract: | Angiogenesis is a multi-step process leading to the formation of new blood vessels from pre-existing vasculature and it is necessary for tumor growth,invasiveness and development of metastasis.Experimental and clinical data demonstrated that breast cancer is an angiogenesis-dependent disease,the vascular endothelial growth factor(VEGF) family plays a key role it being a highly expressed and selective endothelial cell growth factor.Preclinical studies have shown that the angiogenic occurs early in breast cancer development step.Targeting the molecular pathways by biologically-designed treatments is a new therapeutic paradigm aimed to reach tumor growth control. |
| Keywords: | Breast cancer Angiogenesis Antiangiogenic |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |