Development of radioligands for in vivo imaging of GABA(A)-benzodiazepine receptors |
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| Authors: | Katsifis Andrew Kassiou Michael |
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| Affiliation: | Radiopharmaceuticals Division R&D, Australian Nuclear Science and Technology Organisation, Private Mail Bag 1, Menai NSW 2234, Sydney, Australia. akx@ansto.gov.au |
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| Abstract: | Changes in the biochemical integrity and function of the GABA(A)-benzodiazepine receptor (BZR) complex have been implicated in various neurological and psychiatric disorders. The development of specific radioligands for the GABA(A)-BZR have not only contributed to the elucidation of the receptor's biochemical functions, but also provided a means by which these changes are correlated to disease states when studied with the functional imaging modalities of positron emission tomography (PET) and single photon emission computed tomography (SPECT). |
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