| 针灸预刺激对AD大鼠脑内自由基影响的实验研究 |
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| 引用本文： | 柯红,孙国杰,周华. 针灸预刺激对AD大鼠脑内自由基影响的实验研究[J]. 湖北中医药大学学报, 2009, 11(2) |
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| 作者姓名： | 柯红 孙国杰 周华 |
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| 作者单位： | 湖北中医学院,湖北,武汉,430061;湖北中医学院,湖北,武汉,430061;湖北中医学院,湖北,武汉,430061 |
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| 摘 要： | 目的 观察针灸预刺激百会、肾俞穴对阿尔茨海默病(AD)大鼠脑内丙二醛(MDA)含量、谷胱甘肽过氧化物酶(GSH-Px)活性的影响.方法 Aβ25-35注入SD大鼠大脑海马区造模,造模前后采用灸、针、针加灸方法进行治疗,并设正常组、假手术组和模型组.应用分光光度计测定大鼠大脑海马中MDA含量及GSH-Px活性的变化,并与模型组进行比较.结果 针灸预刺激可降低模型动物MDA含量(P＜0.05,P＜0.01),提高GSH-Px活性(P＜0.05,P＜0.01).结论 针灸能清除体内自由基,提高机体的抗氧化能力,减轻脑内自由基对神经元的损伤,从而起到延缓脑老化的作用.
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| 关 键 词： | 阿尔茨海默病 针灸疗法 自由基 丙二醛 谷胱甘肽过氧化物酶 |
Experimental Research of Acupunctural Pre-stimulation on Changing the Level of Cerebral Radicals of AD Rats |
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| KE Hong,SUN Guo-jie,ZHOU Hua. Experimental Research of Acupunctural Pre-stimulation on Changing the Level of Cerebral Radicals of AD Rats[J]. Journal of Hubei University of Chinese Medicine, 2009, 11(2) |
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| Authors: | KE Hong SUN Guo-jie ZHOU Hua |
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| Affiliation: | 1.Master postgraduate in grade 2006;Department of Acupuncture and Traumatology;Hubei University of Chinese Medicine;Wuhan 430061;Hubei Province;China;2.Hubei University of Chinese Medicine;China |
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| Abstract: | Objective To investigate,in the light of radical theory,influences in cerebral contents of malondialdehyde(MDA) and glutathioneperoxdaso(GSH-Px) activity by acupunctural pre-stimulation atBaihui(DU 20) and Shenshu(BL 23) acupoint in rat models of Alzheimer's Disease.Method Changes of cerebral contents of malondialdehyde(MDA) and glutathioneperoxdaso(GSH-Px) activity were determined by spectrophotometry.Results The acupunctural pre-stimulation decreases MDA content and enhances GSH-Px acitivity in model ... |
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