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| 免疫功能对食管癌淋巴结微转移的影响 | |
| 引用本文： | Zimin Qin Bing Li Wenguang Wang. 免疫功能对食管癌淋巴结微转移的影响[J]. 中德临床肿瘤学杂志, 2007, 6(6): 546-548. DOI: 10.1007/s10330-007-0113-5 |
| 作者姓名： | Zimin Qin Bing Li Wenguang Wang |
| 作者单位： | Department of Thoracic Surgery of Henan Tumor Hospital, Zhengzhou 450008, China |
| 摘 要： | Objective： To explore the effect of immune function on lymph node micrometastasis in esophageal cancer patients by the research on the correlation between immune function and micrometastasis. Methods： Ratios of T-lymphocyte subsets CD3＋, CD4＋, CD8＋ and CD4＋/CD8＋ in peripheral blood were examined by flow cytometry, but no lymph node with metastatic cancer cells was observed in middle thoracic esophageal squamous carcinoma patients by routine pathological examination. The patients were divided into 2 groups with or without micrometastasis to detect micrometastasis by immunohistochemical method, and T-lymphocyte subsets levels were compared between the 2 groups. Results： CD3＋ and CD4＋ T-lymphocytes levels of the group with micrometastasis were significantly lower than those of the group without micrometastasis, while CD8＋ level of the group with micrometastasis was significantly higher than that of the group without micrometastasis. Conclusion： T-lymphocyte subset is closely relative with micrometastasis, and prognosis of the patients with low CD3＋ and CD4＋ levels but high CD8＋ T-lymphocytes is comparatively poor. |
| 关 键 词： | 免疫力 食道癌 治疗方法 肿瘤 |
| 收稿时间： | 2007-06-19 |
| 修稿时间： | 2007-08-28 |
Effect of immune function on lymph node micrometastasis in esophageal cancer patients |
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| Zimin Qin,Bing Li,Wenguang Wang. Effect of immune function on lymph node micrometastasis in esophageal cancer patients[J]. The Chinese-German Journal of Clinical Oncology, 2007, 6(6): 546-548. DOI: 10.1007/s10330-007-0113-5 | |
| Authors: | Zimin Qin Bing Li Wenguang Wang |
| Affiliation: | (1) Department of Thoracic Surgery of Henan Tumor Hospital, Zhengzhou, 450008, China |
| Abstract: | Objective: To explore the effect of immune function on lymph node micrometastasis in esophageal cancer patients by the research on the correlation between immune function and micrometastasis. Methods: Ratios of T-lymphocyte subsets CD3 , CD4 , CD8 and CD4 /CD8 in peripheral blood were examined by flow cytometry, but no lymph node with metastatic cancer cells was observed in middle thoracic esophageal squamous carcinoma patients by routine pathological examination.The patients were divided into 2 groups with or without micrometastasis to detect micrometastasis by immunohistochemical method, and T-lymphocyte subsets levels were compared between the 2 groups. Results: CD3 and CD4 T-lymphocytes levels of the group with micrometastasis were significantly lower than those of the group without micrometastasis, while CD8 level of the group with micrometastasis was significantly higher than that of the group without micrometastasis. Conclusion:T-lymphocyte subset is closely relative with micrometastasis, and prognosis of the patients with low CD3 and CD4 levels but high CD8 T-lymphocytes is comparatively poor. |
| Keywords: | esophageal cancer T-lymphocyte subset micrometastasis |
| 本文献已被 CNKI 维普 万方数据 SpringerLink 等数据库收录！ | |