术后患者肠道吸收乳果糖、甘露醇的变化与创伤程度的关系

目的 测定手术后患者肠道对甘露醇和乳果糖吸收的变化,并研究这些变化与手术应激程度的关系。方法 用小剂量乳果糖（ｌａｃｔｕｌｏｓｅ,Ｌ,２ｇ）和甘露醇（ｍａｎｎｉｔｏｌ,Ｍ,１ｇ）的方法测定２０例腹部手术患者术前,术后第５第和１０天乳果糖／甘露醇比值（Ｌ／Ｍ比值）的变化。用急性生理和慢性健康状况评分方法Ⅱ（ＡＰＡＣＨＥⅡ）对患者的创伤程度进行评分。用带电化学检测器的高压液相色谱仪测定尿中的乳果糖和甘

Lactulose mannitol ratio in patients after operation

Objective To study lactulose (lactulose, L) and mannitol (mannitol, M) ratio in urine following operation and investigate the correlation between severity of stress and L/M ratio.ZMethods 20 patients who had received operation were enrolled and each patient was evaluated by APACH scores. L/M permeability study was performed before the operation and 5 and 10 days after the operation. The L and M concentration was analyzed by HPLC with pulsed electrochemical detection (HPLCPED). The correlation between L/M ratio and the severity of surgical stress were related. Results The L/M ratio before the operation was (00230002), increased to (00420005) in the 5th postoperative day (P<001), and then returned to (00240002)(P>005) compared with preoperation in the 10th Postoperation. A significant correlation between the severity of stress and the L/M ratio was observed (r=0762). Conclusions The L/M ratio was increased 5 days after the operation and the L/M ratio was correlated with severity of operative stress.