膀胱癌上皮细胞粘附分子蛋白表达的意义

目的 探讨上皮细胞粘附分子（Ｅ－ＣＤ）表达情况对判断膀胱癌恶性程度、复发及预后的意义。方法 采用免疫组织化学方法对５４例膀胱癌标本中Ｅ－ＣＤ的表达情况进行研究。结果Ｅ－Ｃ原表达情况与膀胱癌的病理分级、分期均有密切关系。（ｘ＾２＝６．６５,Ｐ〈０．０５,Ｘ＾２＝７．１５,Ｐ〈０．０１）。Ｅ－ＣＤ的的民光癌的近期昨发及不良预后有关。（Ｘ＾２＝４．８８,Ｐ〈０．０５;Ｌｏｎｇ－Ｒａｎｋ ｔｅｓｔ;ｘ＾２

E-CD expression and its clinical significance in human bladder carcinoma

OBJECTIVE: To invest the expression of the E-CD protein and its clinical significance in human recurrent bladder transitional cell carcinoma. METHODS: Immunohistological chemistry method was employed to assess the expression of E-CD in 54 cases of bladder transitional cell carcinoma. RESULTS: Decreased E-CD expression correlated with both increased grade and stage (chi(2) = 6.65, P < 0.05; chi(2) = 7.15, P < 0.01). More importantly, abnormal expression of E-CD correlated with the high recurrence in short time and the poor survival (chi(2) = 4.88, P < 0.05; Log-rank test: chi(2) = 4.6, P < 0.05). CONCLUSIONS: The expression of E-CD is an useful parameter of malignancy of carcinoma. The detection of E-CD expression might be significant in determining the malignancy, recurrence and prognosis of bladder transitional cell carcinoma.