Time course of serotonin in platelets from patients with affective disorders

Temporal variations in platelet levels of serotonin were found to be significantly decreased in patients with endogenous affective disorders, particularly those with the bipolar type of manic-depressive psychosis. The time course of serotonin content in these cells was not affected by either the sex or the age of the patients.In vitro incubation with lithium oxybutyrate raised mean platelet serotonin levels and stabilized their fluctuation in platelets from healthy subjects but not in those from the mental patients. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N ^o 3, pp. 240–242, March, 1994 Presented by E. D. Gol'dberg, Member of the Russian Academy of Medical Sciences