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| 罗格列酮对高糖诱导下大鼠肾小球系膜细胞增殖及细胞周期的影响 | |
| 引用本文： | 王战建,王隽,宋庆芳,庞建华. 罗格列酮对高糖诱导下大鼠肾小球系膜细胞增殖及细胞周期的影响[J]. 中华糖尿病杂志, 2007, 15(9): 562-564 |
| 作者姓名： | 王战建 王隽 宋庆芳 庞建华 |
| 作者单位： | 河北医科大学第三医院河北省糖尿病防治中心，河北医科大学第三医院河北省糖尿病防治中心，河北医科大学第三医院河北省糖尿病防治中心，河北医科大学第三医院河北省糖尿病防治中心 |
| 摘 要： | 以大鼠肾小球系膜细胞株(HBZY-1)为靶细胞,观察不同浓度不同时间罗格列酮(RSG)对高糖培养的系膜细胞的作用,发现RSG在一定范围内以剂量和时间依赖关系抑制高糖诱导的肾小球系膜细胞增殖,阻止系膜细胞由G1期进入S期,并诱导细胞凋亡。RSG有效减轻了高糖诱导的肾小球系膜细胞的病理损伤。 |
| 关 键 词： | 罗格列酮 系膜细胞 细胞增殖 细胞周期 |
| 收稿时间： | 2005-12-02 |
| 修稿时间： | 2005-12-02 |
Effect of rosiglitazone on proliferation and cell cycle of rat mesangial cells under high concentration of glucose |
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| WANG Zhan-jian, WANG Jun, SONG Qin-fang,et al.. Effect of rosiglitazone on proliferation and cell cycle of rat mesangial cells under high concentration of glucose[J]. CHINESE JOURNAL OF DIABETES MELLITUS, 2007, 15(9): 562-564 | |
| Authors: | WANG Zhan-jian WANG Jun SONG Qin-fang et al. |
| Affiliation: | The Third Affiliated Hospitol of Hebei Medical University , Shijiazhuang 050051, China |
| Abstract: | Mesangial cells in cell line(HBZY-1) were incubated in different concentrations of rosiglitazone under high glucose condition.Cell number of proliferation was assessed by MTT assay.Cell cycle was measured by flow cytometric analysis.Rosiglitazone can significantly inhibit HBZY-1 proliferation induced by high glucose,induce G1/S transition arrest and increase the apoptosis of mesangial cells.These results indicate that rosiglitazone can effectively protect mesangial cells from the damage induced by high glucose. |
| Keywords: | Rosiglitazone Mesangial cells Cell proliferation Cell cycle |
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