| Abstract: | ![]()
The action of hydrocortisone on the rabbit spleen and the regenerative processes arising after cessation of administration of the hormone were studied. During prolonged administration of hydrocortisone the absorptive function of the reticuloendothelial system is depressed and atrophy of the spleen develops, as shown by a reduction in the weight and size of the organ. Most of the splenic follicles are converted into random clusters of lymphocytes. Pyroninophilic cells disappear from the white pulp. After cessation of the action of the hormone the animal's general condition improves, the development of the atrophic changes in the spleen is halted, the splenic follicles are restored, and the number of pyroninophilic cells in them increases. The use of a regeneration stimulator under these conditions accelerates recovery of the body weight of the animal, reversal of the atrophy of the spleen, and restoration of its normal structure.Department of Histology and Pathological Anatomy, Erevan Zooveterinary Institute. (Presented by Academician of the Academy of Medical Sciences of the USSR A. P. Avtsyn.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 84, No. 12, pp. 722–725, December, 1977. |
