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CY25对^60Co照射所致小鼠白细胞减少症的治疗作用
引用本文:张巍. CY25对^60Co照射所致小鼠白细胞减少症的治疗作用[J]. 中国卫生工程学, 2008, 7(5): 262-263
作者姓名:张巍
作者单位:长春市卫生局卫生监督所,吉林,长春,130033
摘    要:
目的观察长效造血因子CY25对^60Co照射所致小鼠白细胞减少症的治疗作用。方法以^60Co照射的放疗小鼠造成的白细胞减少症为模型,同时设惠尔血阳性对照。结果CY25可提高小鼠白细胞数及中性粒细胞数,在放疗模型中,50~500g/kg的剂量可提高照射动物的WBC、中性粒细胞水平,500g/kg可使照射后动物的最低WBC值提高38%,各给药组动物的WBC水平至少提前10d达到正常值水平。通过对脾脏重量的测定,计算脾脏器系数。结果显示各给药组脾的脏器系数显著高于正常对照组及模型对照组。结论CY25可提高^60Co照射所致的小鼠白细胞减少症动物的白细胞、中性粒细胞水平;给药后可使模型动物的WBC水平至少提前10d达到正常水平;试验结果初步显示CY25具有长效升高白细胞作用。

关 键 词:长效造血细胞生长因子  白细胞减少症  放疗  化疗

The Treatment of CY25 to the Mice Irradiated by 60Co and Induced Leukopenia
ZHANG Wei. The Treatment of CY25 to the Mice Irradiated by 60Co and Induced Leukopenia[J]. Chinese Journal of Public Health Engineering, 2008, 7(5): 262-263
Authors:ZHANG Wei
Affiliation:ZHANG Wei.( Changchun Institute for Health Inspection and Supervision, Changchun Jilin 130033, China)
Abstract:
Objective To observe of long - lasting blood cell growth factor CY25 on the mouse which was caused by exposure to ^60Co leukopenia treatment. Methods The model of mice that was radiated by ^60Co and resulted in leukopenia was used, a positive control group was set up. Results CY25 could rise the numbers of mice's white cell and neutrophile granulocyte. In the radiation model , 50 -500 g/kg dose could improve the level of radiated animal's WBC and neutrophile granulocyte. 500 g/kg enabled the animals after exposure to the minimum value of the WBC to increase 38%, drug - treated animals WBC level of at least 10 days to reach the normal level. Through the determination of the weight of the spleen, the spleen - factor calculation, The results showed that the drug - treated spleen organ coefficient was significantly higher than the normal control group and the control group model. Conclusion CY25 improve the levels of WBC and neutrophils in white blood mice which radiated by ^60Co. After drug - treated the animal model will enable the delivery of the WBC level of at least 10 days to reach normal levels. Preliminary test results show that CY25 can increase the WBC for a long term.
Keywords:Long-term hematopoietic factor  Leucopenia  Radiated  Chemotherapy
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