| 柔脉冲剂毒理学实验研究 |
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| 引用本文： | 顾立,刘剑,吴章怀.柔脉冲剂毒理学实验研究[J].泸州医学院学报,2009,32(2):129-132. |
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| 作者姓名： | 顾立 刘剑 吴章怀 |
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| 作者单位： | 泸州医学院药理教研室,四川泸州,646000 |
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| 摘 要： | 目的：观察柔脉冲剂的急性和长期毒性反应。方法：采用小白鼠最大耐受量测定法和大鼠长期毒性试验进行研究。结果：柔脉冲剂对小鼠灌胃给药的LD50〉201．5克（生药）／kg；大鼠长期毒性试验对动物一般行为活动、体重增长、外周血象、肝肾功能和病理组织学检查与对照组比较无显著性差异（P〉0．05）。结论：柔脉冲剂临床剂量口服安全、无毒。
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| 关 键 词： | 柔脉冲剂 动物 试验 |
TOXICOLOGICAL STUDY OF ROUMAI CHONGJI |
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| Institution: | Gu li,et al (Department of Pharmacology, Luzhou Medical College) |
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| Abstract: | Objective： To abserve acute toxicity as well as long-term toxicity of Roumai Chongji on rats. Method： Maximum endurance doses were determined. Results： LD50 of Ronmaichongji,given orally, was more than 200g （crude drug）/kg,and there was no obvious long-term toxicity on the general conditions,Peripheral blood picture, Function of liver and kidney, and histology in rats.Conclusion： No evident toxicity was found,and its clinical use is safe. |
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| Keywords: | Roumaichongji Animals Experiments |
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