| 全反式维甲酸对乳腺癌MCF-7细胞增殖的影响 |
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| 引用本文： | 傅宏亮,吴靖川,李佳宁,杨念钦,杜学亮. 全反式维甲酸对乳腺癌MCF-7细胞增殖的影响[J]. 上海交通大学学报(医学版), 2005, 25(6): 569-571 |
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| 作者姓名： | 傅宏亮 吴靖川 李佳宁 杨念钦 杜学亮 |
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| 作者单位： | 上海第二医科大学新华医院核医学科,上海,200092;上海第二医科大学新华医院核医学科,上海,200092;上海第二医科大学新华医院核医学科,上海,200092;上海第二医科大学新华医院核医学科,上海,200092;上海第二医科大学新华医院核医学科,上海,200092 |
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| 摘 要： | 目的研究全反式维甲酸(ATRA)对乳腺癌MCF-7细胞增殖的影响。方法采用MTT法观察和比较MCF-7细胞在ATRA不同浓度和作用时间下的增殖能力。结果ATRA作用浓度为1μmol/L时,第3、6、9d的光吸收值均与对照组有显著差异(P<0.01),其中又以第6d时ATRA对MCF-7细胞增殖的抑制作用最明显。结论ATRA对乳腺癌MCF-7细胞具有增殖抑制作用,且这种作用具有剂量和时间依赖性。
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| 关 键 词： | 全反式维甲酸 乳腺癌 细胞增殖 |
| 文章编号： | 0258-5898(2005)06-0569-03 |
| 修稿时间： | 2004-11-15 |
Inhibitive Effect of All-trans Retinoic Acid on Proliferation of Breast Cancer MCF-7 Cells |
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| FU Hong-liang,WU Jing-chuan,LI Jia-ning,YANG Nian-qin,DU Xue-liang. Inhibitive Effect of All-trans Retinoic Acid on Proliferation of Breast Cancer MCF-7 Cells[J]. Journal of Shanghai Jiaotong University:Medical Science, 2005, 25(6): 569-571 |
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| Authors: | FU Hong-liang WU Jing-chuan LI Jia-ning YANG Nian-qin DU Xue-liang |
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| Abstract: | Objective To study the effect of all-trans retinoic acid (ATRA) on proliferation of breast cancer MCF-7 cells. Methods The proliferation of MCF-7 cells under ATRA of different doses and interfering periods was observed and compared by MTT. Results The OD value of the experiment group 3, 6, 9 d after inoculation was significantly variable compared to that of the control group. The inhibiting effect of ATRA on the proliferation of MCF-7 cells was most apparent at 6 d after inoculation. Conclusion ATRA has inhibiting effect on the proliferation of MCF-7 cells, and this effect is dose and time dependent. |
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| Keywords: | all-trans retinoic acid breast cancer cell proliferation |
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