Morphology of MXT mouse mammary tumors. Correlation with growth characteristics and hormone sensitivity |
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| Affiliation: | 1. Department of Psychology, The University of Nebraska-Lincoln, United States of America;2. Center for Brain, Biology, and Behavior, The University of Nebraska-Lincoln, United States of America;1. Division of Urology, A.C. Camargo Cancer Center, São Paulo, Brazil;2. National Institute for Science and Technology in Oncogenomics and Therapeutic Innovation, São Paulo, Brazil.;3. Department of Pathology, Rede D''Or-São Luiz, São Paulo, Brazil.;1. Catalonia Institute for Energy Research (IREC), Jardins de les Dones de Negre 1, 08930 Sant Adrià de Besòs (Barcelona), Spain;2. Universitat Politècnica de Catalunya (UPC), C/Pau Gargallo 5, 08028 Barcelona, Spain |
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| Abstract: | The transplantable MXT mouse mammary tumor has been a useful tool for studying endocrine mechanisms underlying mammary tumor growth. It is our experience, however, that this model is unstable during serial transplantation. This paper analyses this variability from the viewpoints of histology and estrogen receptor content and indicates that these parameters should always be checked before planning experimental work. It is advised that a more homogeneous material is needed and that this goal should be achieved by clonal selection before transplantation. |
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