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Associations of Baseline and Changes in Leukocyte Counts with Incident Cardiovascular Events: The Dongfeng-Tongji Cohort Study
Authors:Qiuhong Wang  Qiang Guo  Lue Zhou  Wending Li  Yu Yuan  Wenhui Lei  Kang Liu  Man Xu  Tingyue Diao  Hui Gao  Meian He  Huan Guo  Handong Yang  Xiaomin Zhang  Tangchun Wu
Affiliation:1.Department of Occupational and Environmental Health and Ministry of Education Key Lab for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;2.Department of Cardiovascular Diseases, Sinopharm Dongfeng General Hospital, Dongfeng Motor Corporation and Hubei University of Medicine, Shiyan, China
Abstract:
Aim: The aim of the present study was to investigate the associations of baseline and longitudinal changes in leukocyte counts with incident cardiovascular disease (CVD). Methods: We conducted a prospective study to investigate the associations of baseline and 5-year changes in leukocyte counts with incident CVD and its subtypes in middle-aged and elderly Chinese. We estimated the hazard ratios (HRs) and 95% confidence intervals (CIs) for CVD using the Cox proportional-hazards models. Results: In the analyses of baseline total leukocyte count of 26,655 participants, compared with the lowest quartile (<4.71×109/L), participants in the fourth quartile (>6.70×109/L) had 11% higher risk for CVD. Consistent with total leukocyte count, neutrophil count also exhibited a significant positive association with the risk of CVD. In the analyses of 5-year changes in total leukocyte count of 11,594 participants, the changes in leukocyte count were categorized into three groups, i.e., the decreased group (<25%), stable group (25%–75%), and increased group (>75%). Compared with participants in the stable group (−1.18 to 0.44×109/L), participants in the increased group (>0.44×109/L) had 14% higher risk for CVD. We also observed significant positive associations of the changes in neutrophil and monocyte counts with the risk of CVD. Furthermore, the total leukocyte count in the second or third tertile at the first follow-up with a 5-year increase was related to higher CVD risk. Conclusion: High baseline total leukocyte count and a 5-year increase in total leukocyte count were related to higher CVD risk.
Keywords:Leukocyte counts   Change   Prospective cohort   Cardiovascular disease
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