In vitro and in vivo activity of 12-O-3-N-dansylamino TPA |
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| Affiliation: | 1. Epilepsy-Center Berlin-Brandenburg, Institute for Diagnostics of Epilepsy, Evangelisches Krankenhaus Königin Elisabeth Herzberge, Berlin, Germany;2. Epilepsy-Center Berlin-Brandenburg, Department of Neurology, Charité –Universitätsmedizin Berlin, Germany;1. The Oskar Klein Centre for Cosmoparticle Physics, Department of Physics, Stockholm University, SE-106 91 Stockholm, Sweden;2. INFN, Sezione di Torino, Via P. Giuria 1, I-10125 Torino, Italy;3. Instituto de Física Corpuscular (CSIC-Universitat de València), Parc Científic UV, C/Catedratico José Beltrán, 2, E-46980 Paterna, Spain;4. Departament de Física Teòrica, Universitat de València, 46100 Burjassot, Spain |
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| Abstract: | ![]()
Dansyl-TPA, a fluorescent TPA analogue, which is a label with a high affinity for C3H/10T1/2 cells and induces 3H-choline release from these cells (Tran et al. Nouv. J. Chim 1984, 8, 751–757), has been studied for in vitro promoting activity in the same cell line initiated by a carcinogen MNNG and in vivo short-term mouse skin tests. In vitro, dansyl-TPA expresses transforming effect in its own (without MNNG pretreatment) as well as increases the production of transformed foci in MNNG-treated cells. In in vivo skin tests, dansyl-TPA displays lower effects than TPA on mouse skin. These results indicate a low promoting potential of dansyl-TPA. |
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