肾素-血管紧张素系统活化、炎性反应与糖尿病关系的研究进展

原发性高血压患者中糖尿病的发病率显著高于非高血压人群。原发性高血压患者体内的肾素-血管紧张素系统(RAS)活性与其血糖水平呈正相关,而阻断RAS的药物可降低原发性高血压患者糖尿病的发病率;高血压患者血浆中炎性因子增加,一些药物可通过抑制炎性反应而阻止高血压患者并发糖尿病。RAS、炎性反应的活化均可通过降低体细胞对胰岛素的敏感性,从而引起或加重胰岛素抵抗或通过破坏胰岛B细胞最终形成糖尿病。

Progress on the Research of Relation between Renin-angiotensin System Activation, Inflammatory and Diabetes

The incidence of diabetic in essential hypertensive population is significantly higher than that of non-hypertensive population.Renin-angiotensin system(RAS)activity in essential hypertensive patients and blood glucose levels are associated,and drugs blocking of RAS can reduce the incidence of diabete in essential hypertensive population;essential hypertensive patients have higher inflammatory factors,some drugs can inhibit the inflammatory response and prevent diabetes mellitus.The inflammation,activated RAS can reduce insulin sensitivity in somatic cells,cause or aggravate insulin resistance,otherwise destroyed islet B cells,eventually cause diabetes.