| 磁共振波谱成像观察多发性硬化与视神经脊髓炎患者丘脑代谢产物 |
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| 引用本文： | 陈璇,李咏梅,罗天友,欧阳羽,吕发金,曾春,王忠平.磁共振波谱成像观察多发性硬化与视神经脊髓炎患者丘脑代谢产物[J].中国介入影像与治疗学,2011,8(5):380-383. |
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| 作者姓名： | 陈璇 李咏梅 罗天友 欧阳羽 吕发金 曾春 王忠平 |
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| 作者单位： | 重庆医科大学附属第一医院放射科,重庆,400016 |
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| 基金项目： | 重庆市卫生局资助项目(2009-2-311、2010-2-004)。 |
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| 摘 要： | 目的利用1H-MRS探讨多发性硬化（MS）及视神经脊髓炎（NMO）患者丘脑代谢产物的变化。方法对32例MS患者（MS组）、28例NMO患者（NMO组）和35名健康志愿者（正常对照组）行丘脑1H-MRS扫描,计算并比较各组丘脑代谢产物比值N-乙酰天门冬氨酸（NAA/Cr）、胆碱/肌酸（Cho/Cr）、肌醇/肌酸（mI/Cr）]。结果三组间NAA/Cr差异有统计学意义（P〈0.05）。与正常对照组比较,MS组丘脑NAA/Cr明显减低（t=-3.45,P〈0.05）,而Cho/Cr及mI/Cr差异无统计学意义（t=0.086、0.661,P均〉0.05）。与正常对照组比较,NMO组丘脑NAA/Cr、Cho/Cr及mI/Cr差异均无统计学意义（t=-0.792、1.408、1.735,P均〉0.05）。结论 1H-MRS显示MS患者丘脑NAA/Cr减低,提示此区域存在轴索损伤,而NMO患者丘脑受损不明显,反映出MS与NMO存在不同的病理变化,有助于二者的鉴别诊断。
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| 关 键 词： | 视神经脊髓炎 多发性硬化 磁共振波谱 丘脑 鉴别诊断 |
| 收稿时间： | 2011/3/31 0:00:00 |
| 修稿时间： | 2011/6/22 0:00:00 |
Magnetic resonance spectroscopy in observing thalamus metabolism of patients with multiple sclerosis or neuromyelitis optica |
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| CHEN Xuan,LI Yong-mei,LUO Tian-you,OUYANG Yu,LV Fa-jin,ZENG Chun and WANG Zhong-ping.Magnetic resonance spectroscopy in observing thalamus metabolism of patients with multiple sclerosis or neuromyelitis optica[J].Chinese Journal of Interventional Imaging and Therapy,2011,8(5):380-383. |
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| Authors: | CHEN Xuan LI Yong-mei LUO Tian-you OUYANG Yu LV Fa-jin ZENG Chun and WANG Zhong-ping |
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| Institution: | Department of Radiology, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China;Department of Radiology, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China;Department of Radiology, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China;Department of Radiology, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China;Department of Radiology, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China;Department of Radiology, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China;Department of Radiology, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China |
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| Abstract: | Objective To investigate the variation of thalamus metabolism in patients with multiple sclerosis(MS) or neuronmyelitis optica(NMO) using 1H-MRS.Methods 1H-MRS was performed to 32 MS patients(MS group),28 NMO patients(NMO group) and 35 healthy volunteers(normal control group).The ratios of metabolism in thalamus,including N-acetylaspartic acid/creatine(NAA/Cr),choline/creatine(Cho/Cr) and myo-inositol/creatine(mI/Cr) were calculated and compared.Results There was statistical difference of NAA/Cr in thalamus... |
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| Keywords: | Neuromyelitis optica Multiple sclerosis Magnetic resonance spectroscopy Thalamus Differential diagnosis |
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