阿仑膦酸钠可抑制骨质疏松性骨折的愈合☆

背景：阿仑膦酸钠作为治疗骨质疏松症的首选药物已被临床广泛应用。 目的：观察阿仑膦酸钠对骨质疏松性骨折大鼠股骨干骨折愈合的影响。 方法：将SD大鼠随机分成3组：假手术组，模型组和阿仑膦酸钠组。模型组及阿仑膦酸钠组于卵巢切除后4周进行右股骨干中段横行骨折，克氏针固定。阿仑膦酸钠组建模后皮下注射阿仑膦酸钠。 结果与结论：骨折造模后3及6周，阿仑膦酸钠组右股骨整体骨密度和远段骨密度高于模型组(P < 0.01)，与模型组相比，阿仑膦酸钠组骨折端骨痂体积大、骨痂数量多，软骨性骨痂向骨性骨痂转换过程延迟，骨折愈合过程减慢，破骨细胞数量显著降低(P < 0.05)。结果证实，阿仑膦酸钠对大鼠骨质疏松性骨折愈合过程有抑制作用，其机制可能与阿仑膦酸钠抑制破骨细胞活性使骨痂钙化过程减慢有关。

Alendronate sodium inhibits femoral fracture healing in osteoporosis rats

BACKGROUND: Alendronate sodium has been preferred for clinical treatment of osteoporosis. OBJECTIVE: To investigate the effects of alendronate sodium on femoral shaft fracture healing in rats with osteoporosis. METHODS: The rats were randomly divided into three groups: sham surgery, model and alendronate sodium. The right femoral diaphysis of rats in the model and alendronate sodium groups was fractured transversely at the midshaft and fixed with Kirschner wire at 4 weeks after ovariectomy. The alendronate sodium group rats were subcutaneously administered alendronate sodium after fracture establishment. RESULTS AND CONCLUSION: At 3 and 6 weeks after fracture establishment, the bone mineral density of the whole femur and distal-segment femur was significantly greater in the alendronate sodium group than in the model group (P < 0.01). Compared with model group, the callus volume was greater, the conversion process of cartilaginous callus towards osseous callus was decreased, femoral fracture healing was slowed, and the number of osteoclasts was significantly decreased (P < 0.05) in the alendronate sodium group. The results demonstrated that alendronate sodium inhibited fracture healing in rats with osteoporosis, and the underlying mechanism may be related to a fact that alendronate sodium inhibits the activity osteoclasts, which slows the callus calcification process.