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| 中药薏苡仁和100Hz电针干预脊髓半横断性大鼠可降低损伤后胶质纤维酸性蛋白表达 | |
| 引用本文： | 侯春光,李忠正,郭义,郭永明,李桂兰,刘阳阳,石田寅夫,王超. 中药薏苡仁和100Hz电针干预脊髓半横断性大鼠可降低损伤后胶质纤维酸性蛋白表达[J]. 中国神经再生研究, 2011, 6(24) |
| 作者姓名： | 侯春光 李忠正 郭义 郭永明 李桂兰 刘阳阳 石田寅夫 王超 |
| 作者单位： | 天津中医药大学实验针灸学研究中心,天津中医药大学实验针灸学研究中心,天津中医药大学实验针灸学研究中心,天津中医药大学实验针灸学研究中心,天津中医药大学实验针灸学研究中心,天津中医药大学实验针灸学研究中心,日本国铃鹿医疗科学大学东洋医学研究所,天津中医药大学实验针灸学研究中心 |
| 基金项目： | the High-funded Projects of Japan Science and Tech-nology Ministry, No. 343*; the National Natural Science Foundation of China, No. 30772838* |
| 摘 要： | 实验建立正常对照组、假手术组、高低频电针组和中药薏苡仁干预组，横断T10左半侧的脊髓损伤模型大鼠，4h后使用5，100Hz电针刺激环跳(GB30)、足三里(ST 36)、至阳(DU9)及悬枢(DU5)或腹腔注射0.4μL中药薏苡仁粗提液(与生药比例为1:1)，连续8周，观察发现低高频电针刺激及薏苡仁治疗能改善脊髓组织损伤区域形态，促进运动诱发电位的恢复，抑制损伤区胶质纤维酸性蛋白表达，改善半横断性脊髓损伤大鼠运动功能，以100Hz电针刺激和薏苡仁干预效果明显。 |
| 关 键 词： | 电针；薏苡仁；半横断脊髓损伤；中医药；神经再生 |
Different frequencies of electroacupuncture and semen coicis decrease glial fibrillary acidic protein expression in rats with hemisection spinal cord injury |
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| Chunguang Hou,Zhongzheng Li,Yi Guo,Yongming Guo,Yangyang Liu,Chao Wang,Ishida Torao Experimental Acupuncture Research Center,Tianjin University of Traditional Chinese Medicine,Tianjin ,China Oriental Medicine Institute of Suzuka Medical Science College,Kishiokachou,Suzuka -,Japan. Different frequencies of electroacupuncture and semen coicis decrease glial fibrillary acidic protein expression in rats with hemisection spinal cord injury[J]. Neural Regeneration Research, 2011, 6(24) | |
| Authors: | Chunguang Hou Zhongzheng Li Yi Guo Yongming Guo Yangyang Liu Chao Wang Ishida Torao Experimental Acupuncture Research Center Tianjin University of Traditional Chinese Medicine Tianjin China Oriental Medicine Institute of Suzuka Medical Science College Kishiokachou Suzuka - Japan |
| Affiliation: | Chunguang Hou1,Zhongzheng Li1,Yi Guo1,Yongming Guo1,Yangyang Liu1,Chao Wang1,Ishida Torao2 1Experimental Acupuncture Research Center,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China 2Oriental Medicine Institute of Suzuka Medical Science College,Kishiokachou,Suzuka 1001-1,Japan |
| Abstract: | This study established the following groups of rats: a normal group, a sham surgery group, a spinal cord injury model group, a low-frequency electroacupuncture group, a high-frequency electroacupuncture group and a semen coicis group. In all but the normal and sham surgery groups, the left half of T10 was transected. Four hours after model induction, 5-Hz and 100-Hz electroacupuncture were used to stimulate the acupoints Huantiao (GB 30), Zusanli (ST 36), Zhiyang (DU 9) and Xuanshu (DU 5), or crude extract from semen coicis was intraperitoneally injected, for 8 consecutive weeks. The results indicated that electroacupuncture stimulation and intraperitoneal injection of semen coicis improved the morphology of spinal cord tissue, promoted the recovery of motion-evoked potentials, suppressed glial fibrillary acidic protein expression, and ameliorated motor function in rats with hemisection spinal cord injury. The effects of high-frequency (100 Hz) electroacupuncture and semen coicis were significant. |
| Keywords: | electroacupuncture semen coicis hemisection spinal cord injury traditional Chinese medicine neural regeneration |
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